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Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition.
TLDR
This study is the first to demonstrate that profound adult hyperphagia is a consequence of fetal programming and a key contributing factor in adult pathophysiology. Expand
Neonatal leptin treatment reverses developmental programming.
TLDR
The complete normalization of the programmed phenotype by neonatal leptin treatment implies that leptin has effects that reverse the prenatal adaptations resulting from relative fetal undernutrition, and is potentially reversible by an intervention late in the phase of developmental plasticity. Expand
The Pathophysiology of Gestational Diabetes Mellitus
TLDR
What is known about the pathophysiology of GDM, and where there are gaps in the literature that warrant further exploration are discussed, are discussed. Expand
Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat
TLDR
Findings indicate that SGAs can cause acute derangements in glucose metabolism that are not caused by a direct induction of insulin resistance but act via an increase in glucagon secretion and thus stimulation of hepatic glucose production. Expand
Early Life Nutrition, Epigenetics and Programming of Later Life Disease
TLDR
A better understanding of the epigenetic basis of developmental programming and how these effects may be transmitted across generations is essential for the implementation of initiatives aimed at curbing the current obesity and diabetes crisis. Expand
Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition.
TLDR
This work is the first to clearly separate prenatal from postnatal effects and shows that lifestyle choices themselves may have a prenatal origin, and predispositions to obesity, altered eating behavior, and sedentary activity are linked and occur independently of postnatal hypercaloric nutrition. Expand
The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy.
TLDR
The results of the present study suggest that leptin's effects are modulated by gender and both prenatal and postnatal nutritional status, and reinforce the importance of leptin in determining long-term energy homeostasis. Expand
Maternal Obesity, Inflammation, and Developmental Programming
TLDR
Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming. Expand
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
TLDR
It is reported that the effects of neonatal leptin on hepatic gene expression and epigenetic status in adulthood are directionally dependent on the animal's nutritional status in utero, suggesting the potential for a discontinuous distribution of environmentally induced phenotypes, analogous to the phenomenon of polyphenism. Expand
Dysregulation of the adipoinsular axis -- a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming.
TLDR
The data suggest that reduced substrate supply during fetal development can trigger permanent dysregulation of the adipoinsular feedback system leading to hyperleptinemia, hyperinsulinism and compensatory leptin production by pancreatic delta-cells in a further attempt to reduce insulin hypersecretion in the progression to adipogenic diabetes. Expand
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