Boron Neutron Capture Therapy of Cancer: Current Status and Future Prospects
- R. Barth, J. Coderre, M. Vicente, T. Blue
- MedicineClinical Cancer Research
- 1 June 2005
Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor borons content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy.
Initiation of Apoptosis and Autophagy by Photodynamic Therapy
- D. Kessel, M. Vicente, John J. Reiners Jr
- BiologyAutophagy
- 27 April 2006
Murine leukemia L1210 cells and human prostate Bax-deficient DU-145 cells were examined after PDT-induced photodamage to the endoplasmic reticulum and autophagy may play a role in the ability of photodynamic therapy to stimulate immunologic recognition of target cells.
Porphyrin-based sensitizers in the detection and treatment of cancer: recent progress.
- M. Vicente
- MedicineCurrent Medicinal Chemistry - Anti-Cancer Agents
- 31 July 2001
It has been known for some time that porphyrins and related compounds have the ability to selectively accumulate in tumor tissues, and to persist there for long periods of time, which has led to their potential use as adjuvants and sensitizers in a variety of medical applications.
Peptide-mediated cell transport of water soluble porphyrin conjugates.
- Martha Sibrian-Vazquez, T. Jensen, R. Hammer, M. Vicente
- Biology, ChemistryJournal of Medicinal Chemistry
- 31 January 2006
Five new porphyrin-peptide conjugates bearing a nuclear localizing sequence SV40 or a fusogenic peptide (HIV-1Tat 40-60 or octa-arginine) linked by low molecular weight poly(ethylene glycol) have…
Synthesis and reactions of meso-(p-nitrophenyl)porphyrins
- R. Luguya, L. Jaquinod, F. Fronczek, M. Vicente, Kevin M Smith
- Chemistry
- 15 March 2004
Synthesis and cellular properties of Near-IR BODIPY–PEG and carbohydrate conjugates
- T. Uppal, N. Bhupathiraju, M. Vicente
- Chemistry, Biology
- 10 June 2013
Intracellular Targeting Specificity of Novel Phthalocyanines Assessed in a Host-Parasite Model for Developing Potential Photodynamic Medicine
- S. Dutta, B. Ongarora, Hairong Li, M. Vicente, B. Kolli, K. Chang
- BiologyPLoS ONE
- 6 June 2011
The in vitro evidence presented here demonstrates for the first time not only the potential of endocytic csPcs for effective photodynamic therapy against Leishmania but also their utility in photo-inactivation of LeishMania to produce a safe carrier to express and deliver a defined antigen with enhanced cell-mediated immunity.
Synthesis, photodynamic activities, and cytotoxicity of new water-soluble cationic gallium(III) and zinc(II) phthalocyanines.
- Rei Fujishiro, Hayato Sonoyama, T. Ikeue
- Chemistry, BiologyJournal of Inorganic Biochemistry
- 1 March 2019
Syntheses and cellular investigations of di-aspartate and aspartate-lysine chlorin e(6) conjugates.
- R. G. W. Jinadasa, Zehua Zhou, M. Vicente, Kevin M Smith
- Chemistry, BiologyOrganic and biomolecular chemistry
- 4 January 2016
The cytotoxicity and uptake of four di(amino acid) chlorin e6 conjugates were investigated in human HEp2 cells, and showed low dark cytoxicity and lower phototoxicity compared with chlorin E6.
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