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Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.
OBJECTIVE The parasympathetic nervous system, through the vagus nerve, can down-regulate inflammation in vivo by decreasing the release of cytokines, including tumor necrosis factor alpha (TNFalpha),… Expand
Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?
Introduction Rheumatoid arthritis (RA) is a chronic, systemic, immune-mediated inflammatory disease associated with decreased life expectancy and quality of life. RA is characterized by chronic… Expand
Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice1
- J. Leemans, N. Juffermans, +5 authors T. van der Poll
- Medicine, Biology
- The Journal of Immunology
- 1 April 2001
Mycobacterium tuberculosis bacilli are intracellular organisms that reside in phagosomes of alveolar macrophages (AMs). To determine the in vivo role of AM depletion in host defense against M.… Expand
Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.
Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-kappaB signaling, as well as late expression of the anti-inflammatory enzyme indoleamine… Expand
The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial…
OBJECTIVE Recent studies have suggested an important role for neurotransmitters as modulators of inflammation. Therefore, we undertook this study to investigate the expression of the alpha7 subunit… Expand
Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.
- J. Leemans, M. Vervoordeldonk, S. Florquin, K. V. van Kessel, T. van der Poll
- American journal of respiratory and critical care…
- 15 May 2002
Lipoteichoic acids (LTA) and peptidoglycans (PepG) are major components of the cell walls of gram-positive bacteria that trigger inflammatory responses in vitro. To study the in vivo effects of LTA… Expand
The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis
The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred to as the 'cholinergic anti-inflammatory pathway'. ACh interacts with… Expand
Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice
- M. A. van Maanen, S. P. Stoof, G. Larosa, M. Vervoordeldonk, P. Tak
- Annals of the rheumatic diseases
- 28 May 2010
Background The α7 subunit of nicotinic acetylcholine receptors (α7nAChR) can negatively regulate the synthesis and release of proinflammatory cytokines by macrophages and fibroblast-like synoviocytes… Expand
Cytokines in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic disease characterized by synovial inflammation that leads to the destruction of cartilage and bone. In the last decade, there was a lot of successful research… Expand
Mice Lacking the Multidrug Resistance Protein 1 Are Resistant to Streptococcus pneumoniae-Induced Pneumonia1
- M. Schultz, J. Wijnholds, +5 authors T. van der Poll
- Biology, Medicine
- The Journal of Immunology
- 15 March 2001
Leukotrienes (LTs) are considered important for antibacterial defense in the lung. Multidrug resistance protein 1 (mrp1) is a transmembrane protein responsible for the cellular extrusion of LTC4. To… Expand