• Publications
  • Influence
Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.
OBJECTIVE The parasympathetic nervous system, through the vagus nerve, can down-regulate inflammation in vivo by decreasing the release of cytokines, including tumor necrosis factor alpha (TNFalpha),Expand
  • 226
  • 11
Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?
Introduction Rheumatoid arthritis (RA) is a chronic, systemic, immune-mediated inflammatory disease associated with decreased life expectancy and quality of life. RA is characterized by chronicExpand
  • 185
  • 8
Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice1
Mycobacterium tuberculosis bacilli are intracellular organisms that reside in phagosomes of alveolar macrophages (AMs). To determine the in vivo role of AM depletion in host defense against M.Expand
  • 208
  • 7
  • PDF
Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.
Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-kappaB signaling, as well as late expression of the anti-inflammatory enzyme indoleamineExpand
  • 127
  • 5
  • PDF
The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial
OBJECTIVE Recent studies have suggested an important role for neurotransmitters as modulators of inflammation. Therefore, we undertook this study to investigate the expression of the alpha7 subunitExpand
  • 76
  • 5
  • PDF
Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus.
Lipoteichoic acids (LTA) and peptidoglycans (PepG) are major components of the cell walls of gram-positive bacteria that trigger inflammatory responses in vitro. To study the in vivo effects of LTAExpand
  • 114
  • 4
  • PDF
The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis
The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred to as the 'cholinergic anti-inflammatory pathway'. ACh interacts withExpand
  • 95
  • 4
Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor α7 subunit gene knockout mice
Background The α7 subunit of nicotinic acetylcholine receptors (α7nAChR) can negatively regulate the synthesis and release of proinflammatory cytokines by macrophages and fibroblast-like synoviocytesExpand
  • 93
  • 4
  • PDF
Cytokines in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic disease characterized by synovial inflammation that leads to the destruction of cartilage and bone. In the last decade, there was a lot of successful researchExpand
  • 87
  • 3
Mice Lacking the Multidrug Resistance Protein 1 Are Resistant to Streptococcus pneumoniae-Induced Pneumonia1
Leukotrienes (LTs) are considered important for antibacterial defense in the lung. Multidrug resistance protein 1 (mrp1) is a transmembrane protein responsible for the cellular extrusion of LTC4. ToExpand
  • 77
  • 3
  • PDF