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The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
- U. Huss, T. Ringbom, P. Perera, L. Bohlin, M. Vasänge
- Chemistry, BiologyJournal of natural products
- 11 September 2002
A rapid semi-homogeneous cyclooxygenase-2 (COX-2) enzymatic assay using scintillation proximity assay (SPA) technology was developed, and 49 ubiquitous plant secondary metabolites were screened for inhibition of COx-2-catalyzed prostaglandin E(2) (PGE(2)) biosynthesis, finding eugenol, pyrogallol, and cinnamaldehyde were found to inhibit COX- 2.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
Increased tau phosphorylation at the Ser396 epitope after amyloid beta-exposure in organotypic cultures
- S. Johansson, A. Jämsä, M. Vasänge, B. Winblad, J. Luthman, R. Cowburn
- 26 June 2006
It is reported that exposure of organotypic hippocampal cultures to synthetic amyloid-&bgr; peptide(25−35) causes neurodegeneration concomitant with a significant increase in tau phosphorylation at the Ser396 epitope.
The flavonoid constituents of two Polypodium species (Calaguala) and their effect on the elastase release in human neutrophils.
Five flavonoid compounds were isolated from two Polypodium species and none of the compounds showed PAF specific activity but showed more general effects on the neutrophil including inhibition of the spontaneous elastase release and potentiation of the release induced by PAF.
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells.
A Sulphonoglycolipid from the Fern Polypodium decumanum and its Effect on the Platelet Activating‐factor Receptor in Human Neutrophils
- M. Vasänge, W. Rolfsen, L. Bohlin
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 1 May 1997
The South American fern Polypodium decumanum, traditional name calaguala, has documented clinical use in oral treatment of skin disorders, including psoriasis. The inflammatory mediator…
Quantitative determination of antiinflammatory principles in some Polypodium species as a basis for standardization.
Assay suitability for natural product screening: searching for leads to fight Alzheimer's disease.
- M. Vasänge
- BiologyPlanta medica
- 1 September 2014
Differences between target-based and phenotypic approaches for identifying new bioactive compounds, as well as strengths and limitations thereof, are described by examples from the therapeutic area of Alzheimer's disease.