M. Vardakou

Publications11
h-index9
Citations571
Highly Influential Citations29
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Enzymic production of a feruloylated oligosaccharide with antioxidant activity from wheat flour arabinoxylan
Summary.Background: Main cereals such as rice, wheat, barley, and corn belong to the family Gramineae and have similar cell-wall composition. Since cereal cell walls are a good source of dietary… Expand
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Evaluation of the prebiotic properties of wheat arabinoxylan fractions and induction of hydrolase activity in gut microflora.
Dietary supplementation with prebiotics may result in the stimulation of the growth of beneficial bacteria such as lactobacilli and bifidobacteria in the human gastrointestinal tract. The effect of… Expand
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Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data
Assessment of the disintegration, dissolution and drug release profiles of oral drug formulations are routinely performed by subjecting them to standard pharmacopeial test methods. However, the… Expand
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Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model.
The disintegration of a capsule shell may determine the onset of drug dissolution from capsule formulations. In this study, the release of a rapidly dissolving model drug (paracetamol), from two… Expand
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In vitro three-stage continuous fermentation of wheat arabinoxylan fractions and induction of hydrolase activity by the gut microflora.
In vitro fermentations were carried out by using a model of the human colon to stimulate microbial activities of gut bacteria. The model consisted of a three-stage culture system. Bacterial… Expand
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Mode of action of family 10 and 11 endoxylanases on water-unextractable arabinoxylan.
Microbial endo-beta-1,4-xylanases (EXs, EC 3.2.1.8) belonging to glycanase families 10 and 11 differ in their action on water-unextractable arabinoxylan (WU-AX). WU-AX was incubated with different… Expand
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Food Matrix Effects of Polyphenol Bioaccessibility from Almond Skin during Simulated Human Digestion
The goal of the present study was to quantify the rate and extent of polyphenols released in the gastrointestinal tract (GIT) from natural (NS) and blanched (BS) almond skins. A dynamic gastric model… Expand
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A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants.
Xylan, which is a key component of the plant cell wall, consists of a backbone of beta-1,4-linked xylose residues that are decorated with arabinofuranose, acetyl, 4-O-methyl d-glucuronic acid and… Expand
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Evaluation of gastric processing and duodenal digestion of starch in six cereal meals on the associated glycaemic response using an adult fasted dynamic gastric model
PurposeTo identify the key parameters involved in cereal starch digestion and associated glycaemic response by the utilisation of a dynamic gastro-duodenal digestion model.MethodsPotential plasma… Expand
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MODE OF ACTION OF TWO THERMOPHYLIC ENDOXYLANASES ON WATER - EXTRACTABLE AND WATER - UNEXTRACTABLE ARABINOXYLAN
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