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Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression.
p15(INK4b) gene is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6 whose expression is induced by transforming growth factor (TGF)beta. Recent reports suggest frequent methylation of the… Expand
p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies.
We analyzed the prognostic value of p53 mutations for response to chemotherapy and survival in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and chronic lymphocytic leukemia (CLL).… Expand
Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoïesis and a high incidence of P53 mutations.
We looked for correlations between cytogenetic rearrangements leading to 17p deletion and presence of dysgranulopoïesis and p53 mutations in MDS and AML. Forty-nine (4.3%) of the MDS and AML studied… Expand
p16 gene homozygous deletions in acute lymphoblastic leukemia.
The p16 protein is a cyclin inhibitor encoded by a gene located in 9p21, which may have antioncogenic properties, and is inactivated by homozygous p16 gene deletion or, less often, point mutation in… Expand
Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.
Mutations of exons 5 to 8 of the p53 gene were looked for in 39 cases of B-cell chronic lymphocytic leukemia (CLL) using polymerase chain reaction single-strand conformation polymorphism analysis and… Expand
Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein
Applications of gene transfer in acute myeloid leukemia (AML) blast cells have still not been developed, mostly due to the lack of an efficient vector. Adenoviruses have many advantages as vectors,… Expand
Mutations of the P53 gene in acute myeloid leukaemia
- P. Fenaux, C. Preudhomme, +7 authors J. P. Kerckaert
- Biology, Medicine
- British journal of haematology
- 1 February 1992
Summary. In a previous report we found point mutations in exons 5–8 of the P53 gene in five of 46 patients with acute myeloid leukaemia (AML), with a predominance of mutations in the 10 patients with… Expand
Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis.
- P. Lepelley, C. Preudhomme, M. Vanrumbeke, B. Quesnel, A. Cosson, P. Fenaux
- Biology, Medicine
- 1 August 1994
The wild type p53 protein has a short half-life and cannot be detected by immunohistochemistry on tissue sections. Mutated p53, on the other hand, has a prolonged half-life and becomes detectable by… Expand
Glutathione S transferase theta 1 gene defects in myelodysplastic syndromes and their correlation with karyotype and exposure to potential carcinogens
Glutathione S transferase theta 1 (GSTT1) is implicated in the detoxification of different substances, including carcinogens. Recently, an increased incidence of GSTT1 null genotype was found in… Expand
Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases.
Exons 5 to 8 of the p53 gene were examined for mutations in 60 patients with B-cell acute lymphoblastic leukemia (ALL), including 50 cases of precursor-B-cell ALL, nine cases of Burkitt (L3) ALL and… Expand