Share This Author
Free radicals and antioxidants in normal physiological functions and human disease.
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
Metals, toxicity and oxidative stress.
This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals.
Advances in metal-induced oxidative stress and human disease.
Role of oxygen radicals in DNA damage and cancer incidence
- M. Valko, M. Izakovič, M. Mazúr, C. Rhodes, J. Telser
- BiologyMolecular and Cellular Biochemistry
- 1 November 2004
The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants.
Arsenic: toxicity, oxidative stress and human disease
Arsenic (As) is a toxic metalloid element that is present in air, water and soil. Inorganic arsenic tends to be more toxic than organic arsenic. Examples of methylated organic arsenicals include…
Metals, oxidative stress and neurodegenerative disorders
- K. Jomová, D. Vondrakova, M. Lawson, M. Valko
- Biology, ChemistryMolecular and Cellular Biochemistry
- 22 August 2010
The role of redox metals Fe and Cu and non-redox metal zinc (Zn) in oxidative stress-related etiology of AD and PD is discussed and several individual antioxidants or their combinations can be neuroprotective and decrease the risk of AD or slow its progression.
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease
Current views regarding the role of redox-active/inactive metal-induced formation of ROS, modifications to biomolecules in human disease such as cancer, cardiovascular disease, metabolic disease, Alzheimer's disease, Parkinson’s disease, renal disease, blood disorders and other disease are summarized.
Importance of iron chelation in free radical-induced oxidative stress and human disease.
The role of iron and importance of iron-chelation in human disease and ageing is discussed and the design of various metal chelators to prevent free radical reactions is an important approach in the treatment of many iron-related diseases.