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Free radicals and antioxidants in normal physiological functions and human disease.
Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing. Expand
Free radicals, metals and antioxidants in oxidative stress-induced cancer.
This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors. Expand
Metals, toxicity and oxidative stress.
This review summarizes recent findings in the metal-induced formation of free radicals and the role of oxidative stress in the carcinogenicity and toxicity of metals. Expand
Advances in metal-induced oxidative stress and human disease.
An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided. Expand
Role of oxygen radicals in DNA damage and cancer incidence
The epidemiological trials together with in vitro experiments suggest that the optimal approach is to reduce endogenous and exogenous sources of oxidative stress, rather than increase intake of anti-oxidants. Expand
Metals, oxidative stress and neurodegenerative disorders
The role of redox metals Fe and Cu and non-redox metal zinc (Zn) in oxidative stress-related etiology of AD and PD is discussed and several individual antioxidants or their combinations can be neuroprotective and decrease the risk of AD or slow its progression. Expand
Arsenic: toxicity, oxidative stress and human disease
Arsenic (As) is a toxic metalloid element that is present in air, water and soil. Inorganic arsenic tends to be more toxic than organic arsenic. Examples of methylated organic arsenicals includeExpand
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD. Expand
Importance of iron chelation in free radical-induced oxidative stress and human disease.
The role of iron and importance of iron-chelation in human disease and ageing is discussed and the design of various metal chelators to prevent free radical reactions is an important approach in the treatment of many iron-related diseases. Expand
Redox- and non-redox-metal-induced formation of free radicals and their role in human disease
Current views regarding the role of redox-active/inactive metal-induced formation of ROS, modifications to biomolecules in human disease such as cancer, cardiovascular disease, metabolic disease, Alzheimer's disease, Parkinson’s disease, renal disease, blood disorders and other disease are summarized. Expand