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Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Using multiple mouse in vivo thrombosis models, it is demonstrated that genetic deletion of Cd36 protects mice from hyperlipidemia-associated enhanced platelet reactivity and the accompanying prothrombotic phenotype. Expand
Gravidity-Dependent Production of Antibodies That Inhibit Binding of Plasmodium falciparum-Infected Erythrocytes to Placental Chondroitin Sulfate Proteoglycan during Pregnancy
ABSTRACT During pregnancy, Plasmodium falciparum-infected erythrocytes sequester in the placenta by adhering to chondroitin 4-sulfate, creating a risk factor for both the mother and the fetus. TheExpand
Characterization of Proteoglycans of Human Placenta and Identification of Unique Chondroitin Sulfate Proteoglycans of the Intervillous Spaces That Mediate the Adherence ofPlasmodium
The identification and characterization of chondroitin sulfate proteoglycans of human placenta provide a valuable tool for understanding the precise molecular interactions involved in placental IRBC adherence and for the development of therapeutic strategies for maternal malaria. Expand
Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice.
The data suggest that repeated blast exposures lead to increased impairment severity in multiple neurological parameters of TBI in mice. Expand
Structural Requirements for the Adherence ofPlasmodium falciparum-infected Erythrocytes to Chondroitin Sulfate Proteoglycans of Human Placenta*
The structural requirements for the adherence and the minimum chondroitin 4-sulfate (C4S) structural motif that supports IRBC adherence are reported, indicating that a dodecasaccharide is the minimum structural motif required for optimalIRBC adherence. Expand
Novel role of the muskelin–RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
A role for muskelin–RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication is identified and is associated with RanBP9/RanBPM. Expand
Mapping and Characterization of the Binding Site for Specific Oxidized Phospholipids and Oxidized Low Density Lipoprotein of Scavenger Receptor CD36*
Data indicate that CD36 (160-168) represents the core of the oxPCCD36 binding site with lysines 164/166 being indispensable for the binding. Expand
Structural characterization of the bovine tracheal chondroitin sulfate chains and binding of Plasmodium falciparum-infected erythrocytes.
This study revealed the distribution pattern of 4- and 6-sulfate in bovine tracheal CSA and structural basis for IRBC binding and adherence inhibition analysis. Expand
Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI.
It is reported that OxHDL, but not native HDL, is a potent inhibitor of platelet activation and aggregation induced by physiologic agonists, and contrary to the prothrombotic activity of oxidized low-density lipoprotein (OxLDL), HDL upon oxidation acquires antithromBotic activity that depends on platelet SR-BI. Expand
The Low Sulfated Chondroitin Sulfate Proteoglycans of Human Placenta Have Sulfate Group-clustered Domains That Can Efficiently Bind Plasmodium falciparum-infected Erythrocytes*
The data demonstrate, for the first time, the unique distribution of sulfate groups in the CS chains of placental CSPGs and that these sulfate-clustered domains have the necessary structural elements for the efficient adhesion of IRBCs, although theCS chains have an overall low degree of sulfation. Expand