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Mutations in Desmoglein-2 Gene Are Associated With Arrhythmogenic Right Ventricular Cardiomyopathy
The presence of mutations in desmosomal encoding genes in 40% of cases confirms that many forms of ARVC are due to alterations in the desmosome complex.
Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis?
- C. Basso, G. Thiene, D. Corrado, A. Angelini, A. Nava, M. Valente
- 1 September 1996
In the fibrofatty variety of ARVC, the myocardial atrophy appears to be the consequence of acquired injury and repair (fibroFatty replacement), mediated by patchy myocarditis.
Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies.
The ultrastructural evidence of intercalated discs remodelling in ARVC, together with the positive screening of D protein encoding genes in half of probands, are in keeping with an intercellular junction cardiomyopathy.
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy
It is demonstrated for the first time that myocyte necrosis is the key initiator of myocardial injury, triggering progressiveMyocardial damage, including an inflammatory response and massive calcification within the myocardium, followed by injury repair with fibrous tissue replacement, and myocardia atrophy.
Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection.
Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV‐RNA levels
The concept that immune‐mediated apoptosis may play a role in the pathogenesis of chronic hepatitis C is supported and this type of reaction may occur in the absence of significant alanine transaminase (ALT) elevation, thus explaining the lack of correlation between biochemical activity and liver histological damage.
Molecular Diagnosis of Myocarditis and Dilated Cardiomyopathy in Children: Clinicopathologic Features and Prognostic Implications
- F. Calabrese, E. Rigo, G. Thiene
- Medicine, BiologyDiagnostic molecular pathology : the American…
- 1 December 2002
Viral etiology of myocarditis/dilated cardiomyopathy (DCM) in children and correlated molecular findings with pathologic and clinical data appeared to be a more severe disease than nonviral forms.
Surgical pathology of primary cardiac and pericardial tumors.
Immune and Nonimmune Predictors of Cardiac Allograft Vasculopathy Onset and Severity: Multivariate Risk Factor Analysis and Role of Immunosuppression
An immune basis for CAV onset and nonimmune modulation for progression is suggested and high RS for severe grades may provide a predictor for patients at risk of heart transplantation.
Cerebral Protection During Carotid Artery Stenting: Collection and Histopathologic Analysis of Embolized Debris
By the use of distal protection filters during carotid artery stenting, it was possible to collect particulate debris potentially leading to distal vessel occlusion in a high percentage of cases.