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Mutations in Desmoglein-2 Gene Are Associated With Arrhythmogenic Right Ventricular Cardiomyopathy
TLDR
The presence of mutations in desmosomal encoding genes in 40% of cases confirms that many forms of ARVC are due to alterations in the desmosome complex. Expand
Ultrastructural evidence of intercalated disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron microscopy investigation on endomyocardial biopsies.
TLDR
The ultrastructural evidence of intercalated discs remodelling in ARVC, together with the positive screening of D protein encoding genes in half of probands, are in keeping with an intercellular junction cardiomyopathy. Expand
Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis?
TLDR
In the fibrofatty variety of ARVC, the myocardial atrophy appears to be the consequence of acquired injury and repair (fibroFatty replacement), mediated by patchy myocarditis. Expand
Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection.
TLDR
The role of the CXCR3/CXCL10 interactions in the recruitment of lymphocytes at sites of lung rejection is indicated and a rationale for the use of agents that block the CxCR3 /CxCL10 axis in the treatment of lung allograft rejection is provided. Expand
Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy
TLDR
This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate. Expand
Surgical pathology of primary cardiac and pericardial tumors.
TLDR
Although the diagnosis of cardiac masses is easily attainable by routine imaging techniques, differential diagnosis between primary and secondary tumors, malignant and benign forms, and non neoplastic masses, is achievable only by a thorough microscopic study of surgical resections. Expand
Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV‐RNA levels
TLDR
The concept that immune‐mediated apoptosis may play a role in the pathogenesis of chronic hepatitis C is supported and this type of reaction may occur in the absence of significant alanine transaminase (ALT) elevation, thus explaining the lack of correlation between biochemical activity and liver histological damage. Expand
Molecular Diagnosis of Myocarditis and Dilated Cardiomyopathy in Children: Clinicopathologic Features and Prognostic Implications
TLDR
Viral etiology of myocarditis/dilated cardiomyopathy (DCM) in children and correlated molecular findings with pathologic and clinical data appeared to be a more severe disease than nonviral forms. Expand
In vivo evidence of apoptosis in arrhythmogenic right ventricular cardiomyopathy.
TLDR
In conclusion, apoptosis is present in endomyocardial biopsies of patients with ARVC, especially in the early symptomatic phase of disease. Expand
Immune and Nonimmune Predictors of Cardiac Allograft Vasculopathy Onset and Severity: Multivariate Risk Factor Analysis and Role of Immunosuppression
TLDR
An immune basis for CAV onset and nonimmune modulation for progression is suggested and high RS for severe grades may provide a predictor for patients at risk of heart transplantation. Expand
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