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Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy.
- G. Merlino, A. Piani, +4 authors G. Gigli
- Nephrology, dialysis, transplantation : official…
The questionnaire showed a high presence of sleep disruption in dialytic populations, and might help nephrologists to deal with uraemic patients with possible sleep disorders. Expand
Prevalence of 'poor sleep' among patients with multiple sclerosis: an independent predictor of mental and physical status.
Poor sleep is common in patients with multiple sclerosis, representing an independent predictor of QoL, and patients with MS who are poor sleepers should receive immediate assessment and treatment, bearing in mind that other clinical conditions can disrupt nocturnal sleep. Expand
Sleep organization pattern as a prognostic marker at the subacute stage of post-traumatic coma
- M. Valente, F. Placidi, +4 authors G. Gigli
- Medicine, Psychology
- Clinical Neurophysiology
- 1 November 2002
It is demonstrated that the sleep-wake organization pattern based on 24h polysomnographic recordings at the subacute stages of post-traumatic coma is a reliable prognostic marker, both for survival and for functional recovery. Expand
The importance of polysomnography in the evaluation of prolonged disorders of consciousness: sleep recordings more adequately correlate than stimulus-related evoked potentials with patients' clinical…
PSG recordings have proved to be a reliable tool in the neurophysiologic assessment of patients with prolonged DOCs, correlating more adequately than EPs with the clinical evaluation and the level of consciousness. Expand
Are Early Seizures Predictive of Epilepsy after a Stroke? Results of a Population-Based Study
All acute conditions related to the occurrence of stroke are implicated in the pathogenesis of ES, which becomes a risk factor for LS only in the setting of intracerebral hemorrhages, therefore, early antiepileptic treatment is needed only in this situation. Expand
Restless legs syndrome in end-stage renal disease.
The high prevalence of RLS and other sleep disorders among uremics requires careful investigation of nocturnal sleep; although often underdiagnosed, correct identification of these disorders can lead to better therapy and improvement of clinical conditions and quality of life. Expand
Association of restless legs syndrome in type 2 diabetes: a case-control study.
This is the first controlled study confirming a significant association between RLS and type 2 diabetes and suggests polyneuropathy only partially explains the increased prevalence of RLS in type 2 diabetics. Expand
Daytime sleepiness is associated with dementia and cognitive decline in older Italian adults: a population-based study.
Insomnia, the most common sleep complaint in the sample, was not associated with the presence of cognitive decline, and excessive daytime sleepiness was significantly related to dementia. Expand
ADMET considerations for restless leg syndrome drug treatments
- Stefano de Biase, G. Merlino, S. Lorenzut, M. Valente, G. Gigli
- Expert opinion on drug metabolism & toxicology
- 18 September 2012
The present review focuses on the Absorption, Distribution, Metabolism, Elimination and Toxicology (ADMET) characteristics of the most used medications for RLS, and the ADMET characteristics of dopaminergic agents, anticonvulsants able to improve neuropathic pain, and iron were discussed. Expand
Incidence of Transient Ischemic Attack and Early Stroke Risk: Validation of the ABCD2 Score in an Italian Population-Based Study
This study adds new data on TIA incidence and prognosis and it further validates the ability of the ABCD2 score to identify patients at early risk for stroke. Expand