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Modern diagnosis of GERD: the Lyon Consensus
TLDR
Future GERD management strategies should focus on defining individual patient phenotypes based on the level of refluxate exposure, mechanism of refux, efficacy of clearance, underlying anatomy of the oesophagogastric junction and psychometrics defining symptomatic presentations.
View on BMJ
ACG Clinical Guideline: Diagnosis and Management of Achalasia
TLDR
This ACG guideline presents an evidence-based approach in patients with achalasia based on a comprehensive review of the pertinent evidence and examination of relevant published data.
View on Nature
American Gastroenterological Association Medical Position Statement on the management of gastroesophageal reflux disease.
TLDR
The American Gastroenterological Association (AGA) Institute Medical Position Panel consisted of the authors of the technical review, an insurance provider representative, a community-based gastroenterologist, and the Chair of the AGA Institute Clinical Practice and Quality Management Committee.
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Etiology and Pathogenesis of Achalasia: The Current Understanding
TLDR
Current evidence suggests that the initial insult to the esophagus results in myenteric plexus inflammation, which leads to an autoimmune response in a susceptible population who may be genetically predisposed to achalasia.
View on Wolters Kluwer
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
TLDR
An updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement, and the evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EOE than as a diagnostic criterion.
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Role of acid and duodenogastroesophageal reflux in gastroesophageal reflux disease.
TLDR
Both acid and DGER show a graded increase in severity across the gastroesophageal reflux disease (GERD) spectrum.
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American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease.
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Cytokeratin subsets can reliably distinguish Barrett's esophagus from intestinal metaplasia of the stomach.
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Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0©
TLDR
Key updates in CCv4.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction ( EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics.
View on Wiley
Long-term effect of H2RA therapy on nocturnal gastric acid breakthrough.
TLDR
The combination of H2RA and PPI therapy reduced NAB only with the introduction of therapy, and there was no difference in acid suppression between PPI twice daily and P PI twice daily + H2 RA after 1 week of combination therapy.
View on PubMed
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