• Publications
  • Influence
Agents that increase the permeability of the outer membrane.
  • M. Vaara
  • Biology, Medicine
  • Microbiological reviews
  • 1 September 1992
TLDR
Chelators (such as EDTA, nitrilotriacetic acid, and sodium hexametaphosphate), which disintegrate the outer membrane by removing Mg2+ and Ca2+, are effective and valuable permeabilizers. Expand
Molecular basis of bacterial outer membrane permeability.
TLDR
It is becoming increasingly clear that the outer membrane is very important in the physiology of gram-negative bacteria in making them resistant to host defense factors such as lysozyme, P-lysin, and various leukocyte proteins. Expand
Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland.
TLDR
The results indicate that increased probiotic use of L. rhamnosus GG has not led to an increase in Lactobacillus bacteremia. Expand
Safety of probiotics that contain lactobacilli or bifidobacteria.
TLDR
Vigilance regarding the detection of possible rare cases of infection due to probiotics should be maintained, and isolates should be sent to reference centers for molecular characterization and confirmation. Expand
Lipopolysaccharides of polymyxin B‐resistant mutants of Escherichia coii are extensively substituted by 2‐aminoethyl pyrophosphate and contain aminoarabinose in lipid A
TLDR
The polymyxin resistance was shown to be associated, along with the esterification of the lipid A 4′‐monophosphate by aminoarabinose, with extensive esterization of diphosphates in LPS by 2‐aminoethanol. Expand
Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide
TLDR
It is shown that it is possible to sensitizeasive Gram-negative enteric bacteria to both complement and antibiotics by using an agent that binds to the outer membrane, which is a nontoxic derivative of polymyxin which by itself has no bactericidal action. Expand
Increased substitution of phosphate groups in lipopolysaccharides and lipid A of the polymyxin‐resistant pmrA mutants of Salmonella typhimurium: a 31P‐NMR study
TLDR
De‐O‐acylated lipopolysaccharides of three polymyxin‐resistant Salmonella typhimurium pmrA mutants and their parent strains were analysed by 31P‐NMR (nuclear magnetic resonance) in order to assess the types and degree of substitution of phosphates of the LPS and lipid A. Expand
Streptococcus mutans Clonal Variation Revealed by Multilocus Sequence Typing
TLDR
It is concluded that the ancestral strain of S. mutans was serotype c, and the superior discriminatory capacity of this multilocus sequence typing (MLST) scheme for S. Mutans may have important practical implications. Expand
Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria
  • M. Vaara
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 1 February 1993
TLDR
The results indicate that azithromycin and the other new macrolides use the hydrophobic pathway across the outer membrane and that the intact outer membrane is an effective barrier against them, and that azITHromycin, in contrast to polymyxin, does not effectively diffuse through the outer membranes by interacting electrostatically with the lipopolysaccharide. Expand
Outer Membrane Permeability Barrier Disruption by Polymyxin in Polymyxin-Susceptible and -Resistant Salmonella typhimurium
  • M. Vaara, T. Vaara
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 April 1981
TLDR
Polymyxin-resistant Salmonella typhimurium mutants (pmrA strains) did not lose their outer membrane permeability barrier to macromolecules such as lysozyme and periplasmic proteins upon polymyXin treatment, suggesting a degree of specificity in the pmrA effect in the outer membrane. Expand
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