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ChIP‐Seq of ERα and RNA polymerase II defines genes differentially responding to ligands
TLDR
E2‐activated and E2‐repressed genes are identified preferentially regulated by tamoxifen but not by E2 or fulvestrant, and (partial) antagonist loaded ERα acts mechanistically different on E2 •activated‐and‐ repressed genes. Expand
Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum
TLDR
An unforeseen and unique plasticity in the use of the epigenetic marks is revealed and implies the presence of distinct epigenetic pathways in gene silencing/activation throughout the erythrocytic cycle. Expand
Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells
TLDR
Through a DNA array-based genome-wide analysis of TCF4 chromatin occupancy, 6,868 high-confidenceTCF4-binding sites are identified in the LS174T colorectal cancer cell line and significantly correlate with Wnt-responsive gene expression profiles derived from primary human adenomas. Expand
Characterization of genome-wide p53-binding sites upon stress response
TLDR
The majority of the genome-wide p53 target sites can also be bound by overexpressed p63 and p73 in vivo, suggesting that they can possibly play an important role at p53 binding sites. Expand
Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR.
TLDR
Results show that mutations in the ABCR gene not only result in STGD and AMD, but can also cause autosomal recessive RP and CRD. Expand
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes
TLDR
Seven independent computational disease gene prioritization methods are reviewed, and then applied to the analysis of 9556 positional candidate genes for type 2 diabetes (T2D) and the related trait obesity. Expand
The 2588G-->C mutation in the ABCR gene is a mild frequent founder mutation in the Western European population and allows the classification of ABCR mutations in patients with Stargardt disease.
TLDR
It is hypothesized that the 2588G-->C alteration is a mild mutation that causes Stargardt disease only in combination with a severe ABCR mutation, and homozygosity for this and other mild ABCR mutations probably does not result in an STGD phenotype. Expand
A model for the topology of active ribosomal RNA genes
TLDR
It is shown that the promoter, upstream region and terminator R3 of active rRNA genes are held together spatially throughout the cell cycle, forming a stable core around which the transcribed region is organized. Expand
ABCR unites what ophthalmologists divide(s)
TLDR
It is hypothesized that most ABCR mutations can be classified in different classes of severity, and that, depending on the remaining total activity of ABCR, the phenotype can range from AMD at the mild end to RP at the severe end of the spectrum. Expand
Identification of novel functional TBP‐binding sites and general factor repertoires
TLDR
This study broadens the spectrum of general transcription factor function and uncovers a plethora of novel, functional TATA‐binding protein (TBP)‐binding sites in the human genome. Expand
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