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Therapeutic antibodies: successes, limitations and hopes for the future
With more than 20 molecules in clinical use, monoclonal antibodies have finally come of age as therapeutics, generating a market value of $11 billion in 2004, expected to reach $26 billion by 2010.Expand
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Isolation of viral IgY antibodies from yolks of immunized hens.
Antibodies were isolated from the yolks of hens that were immunized with a variety of plant viruses by the use of polyethylene glycol (PEG). A concentration of 3.5% of the polymer caused the lipidsExpand
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The increased incidence of pure red cell aplasia with an Eprex formulation in uncoated rubber stopper syringes.
BACKGROUND The incidence of pure red cell aplasia (PRCA) in chronic kidney disease patients treated with epoetins increased substantially in 1998, was shown to be antibody mediated, and wasExpand
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Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools
A workshop, sponsored by the National Institute of Allergy and Infectious Disease (NIAID), was recently held in Washington, DC to discuss the current state of the B‐cell epitope prediction field. Expand
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Arthritogenic Monoclonal Antibodies from K/BxN Mice
Arthritis in the K/BxN mouse model is provoked by pathogenic antibodies (Abs) directed against a ubiquitously expressed protein, glucose-6-phosphate isomerase (GPI). To begin dissecting theExpand
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Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein.
Sixteen overlapping fragments of the dengue-2 virus envelope (E) protein, expressed as trpE-E fusion products in Escherichia coli, were used to map the epitopes defined by a panel of 20 monoclonalExpand
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Synthetic peptides as antigens: pitfalls of conjugation methods.
Peptide-carrier conjugates were prepared using 9 different synthetic peptides, 3 carrier proteins and 4 coupling reagents. Residues of the carrier protein that were modified by different couplingExpand
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Predicting location of continuous epitopes in proteins from their primary structures.
Publisher Summary This chapter describes epitopes that are considered as “functional epitopes”—that is, portions or fragments of a protein that are able to bind to antibody in an immunoassay—and notExpand
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Correlation between the location of antigenic sites and the prediction of turns in proteins.
In the present study, we developed new turn scales based on the occurrence of amino acids at each of the four positions of a turn using a structural database comprised of 87 proteins. We found thatExpand
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Comparison of molecular and immunological typing of isolates of Rice yellow mottle virus
Summary. Isolates of Rice yellow mottle virus (RYMV) were typed at the molecular level through the sequences of the open reading frame (ORF) 4 (coding for the coat protein) and ORF1 (coding for theExpand
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