• Publications
  • Influence
High‐fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. We hypothesized that mice exposed to a similar dietExpand
  • 280
  • 13
HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma.
BACKGROUND The percentage of reduced coenzyme Q(10) (CoQ(10)H(2)) in total coenzyme Q(10) (TQ(10)) is decreased in plasma of patients with prematurity, hyperlipidemia, and liver disease. CoQ(10)H(2)Expand
  • 158
  • 7
  • PDF
Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection.
BACKGROUND Ubiquinone-responsive multiple respiratory chain dysfunction due to coenzyme Q(10) (CoQ(10)) deficiency has been previously identified in muscle biopsies. However, previous methods areExpand
  • 70
  • 5
Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies.
Coenzyme Q10 content, pathology evaluation, and electron transport chain (ETC) enzyme analysis were determined in muscle biopsy specimens of 82 children with suspected mitochondrial myopathy. DataExpand
  • 41
  • 5
  • PDF
Bioequivalence of coenzyme Q10 from over-the-counter supplements
Abstract The objective of this study was to compare the relative bioavailability of two new products with solubilized and non-solubilized over-the-counter (OTC) coenzyme Q 10 products. Nine healthyExpand
  • 73
  • 5
  • PDF
Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats.
Dietary protein restriction in young rats stunts growth and decreases serum insulin-like growth factor I (IGF-I) concentrations. To investigate the possibility of a diet-induced accelerated clearanceExpand
  • 78
  • 4
Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults.
BACKGROUND Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described,Expand
  • 83
  • 4
Topiramate Pharmacokinetics in Infants
Summary: Purpose: This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open‐label trial ofExpand
  • 63
  • 4
Feasibility and Acceptance of Salivary Monitoring of Antiepileptic Drugs Via the US Postal Service
Salivary and serum levels of phenobarbital, carbamazepine, and phenytoin are closely correlated. Salivary monitoring of antiepileptic drugs has a number of advantages including the potential for homeExpand
  • 17
  • 4
Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stressExpand
  • 44
  • 3