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A new lignan glycoside and phenylethanoid glycosides from Strobilanthes cusia BREMEK.
Lupeol showed anti-HSV-1 activity and showed 100% inhibition of virus plaque formation at 58.7 microM, and two new phenylethanoid glycosides were found together with five known compounds as chemical constituents of Strobilanthes cusia root.
Transmission of Helicobacter pylori infection via flexible fiberoptic endoscopy.
Inhibition of Hyaluronidases and Chondroitinases by Fatty Acids
- Keitarou Suzuki, Yoshikazu Terasaki, M. Uyeda
- Biology, ChemistryJournal of enzyme inhibition and medicinal…
- 1 January 2002
The inhibitory effects of various fatty acids on three hyaluronidases and four chondroitinases were examined, and their structure-activity relationships and mechanism of action were studied.
A new antiherpetic agent, AH-135Y, produced by Streptomyces albovinaceus strain No. AH-135.
Anti-herpes virus type 1 activity of oleanane-type triterpenoids.
- T. Ikeda, K. Yokomizo, M. Uyeda
- Chemistry, BiologyBiological & pharmaceutical bulletin
- 1 September 2005
The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were…
Enhanced reporter gene expression in cells transfected in the presence of DMI-2, an acid nuclease inhibitor
The hypothesis that nuclease action is a significant barrier to expression of foreign genes and inhibition of specific nucleases may facilitate transfection is supported.
Partial Amino Acid Sequence of an Alkaline Protease Inhibitor, API-2 (b and c)
The amino acid sequence around the reactive site of API-2 (b and c) was very similar to that of S-SI (Streptomyces subtilisin inhibitor) with the exception of the isoleucine residue in place of valine residue i...
Inhibition of Topoisomerases by Fatty Acids
- Keitarou Suzuki, F. Shono, H. Kai, T. Uno, M. Uyeda
- ChemistryJournal of enzyme inhibition
- 1 January 2000
Petroselinic acid was a topoisomerase inhibitor of the cleavable complex-nonforming type and acted directly on the enzyme molecule in a noncompetitive manner without DNA intercalation.
Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities.
A novel inhibitor of topoisomerases designated as topostatin was isolated from the culture filtrate of Thermomonospora alba strain No. 1520, but did not exhibit any antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts and fungi.
Synthesis of 2,2'-dihydroxybisphenols and antiviral activity of some bisphenol derivatives.
New diphenylmethane-type 2,2'-dihydroxybisphenols (5a-d) were prepared regioselectively in good yields and some bisphenol derivatives synthesized by the plaque reduction assay showed significant antiviral activity.