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Rediocides A and G as Potential Antitoxins Against Cobra Venom
Rediocides A and G, the principle components of Trigonostemon reidioides (Kurz) Craib, which is known as Lotthanong in Thai, were investigated for a detoxification mechanism against Naja kaouthiaExpand
Virtual Screening Against α-Cobratoxin
α-Cobratoxin (Cbtx), the neurotoxin isolated from the venom of the Thai cobra Naja kaouthia , causes paralysis by preventing acetylcholine (ACh) binding to nicotinic acetylcholine receptors (nAChRs).Expand
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.
Acetylcholinesterase (AChE) inhibitory activity is one of the proposed targets for indole analogs. Simple indoles with substitution of methoxy, carboxy or hydroxy at the benzene ring showed a lowExpand
5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases.
NP506, the 3-{2,4-dimethyl-5-[2-oxo-5-(N'-phenylhydrazinocarbonyl)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid, was designed as FGF receptor 1 inhibitor by computational studyExpand
Parallel synthesis of "click" chalcones as antitubulin agents.
It has been shown that some chalcones are able to inhibit tubulin polymerization, giving cytotoxicity and destruction of tumoral vasculature. A library of 180 novel chalcone analogs has beenExpand
Virtual Screening against Acetylcholine Binding Protein
The nicotinic acetylcholine receptors (nAChRs) are a member of the ligand-gated ion channel family and play a key role in the transfer of information across neurological networks. The X-ray crystalExpand
Interruptin B induces brown adipocyte differentiation and glucose consumption in adipose-derived stem cells
Interruptin B has been isolated from Cyclosorus terminans, however, its pharamcological effect has not been fully identified. In the present study, the effects of interruptin B, from C. terminans, onExpand
The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.
AIMS The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS TheExpand
Comparison between Volatile Oil from Fresh and Dried Fruits of Zanthoxylum rhetsa (Roxb.) DC. and Cytotoxicity Activity Evaluation
Introduction: Zanthoxylum rhetsa is a tree found in northern Thailand. It has been used as a traditional herb with medicinal properties. However, the comparison of composition in volatile oil fromExpand