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Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion.
Palatal fusion is a complex, multi-step developmental process; the consequence of failure in this process is cleft palate, one of the most common birth defects in humans. Previous studies have shownExpand
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Heteropagus (parasitic) twins: a review.
Heteropagus, or "parasitic," twins are asymmetric conjoined twins in which the tissues of a severely defective twin (parasite) are dependent on the cardiovascular system of the other, largely intactExpand
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Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.
Patients with mutations in either TGF-β receptor type I (TGFBR1) or TGF-β receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated TGF-βExpand
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Partial craniofacial duplication: a review of the literature and case report.
Diprosopus (Greek; di-, "two" + prosopon, "face"), or craniofacial duplication, is a rare craniofacial anomaly referring to the complete duplication of facial structures. Partial craniofacialExpand
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TGFβ-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development
The murine frontal bone derives entirely from the cranial neural crest (CNC) and consists of the calvarial (lateral) aspect that covers the frontal lobe of brain and the orbital aspect that forms theExpand
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Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing.
Members of the transforming growth factor-beta (TGF-beta) superfamily are critical regulators for wound healing. Transduction of TGF-beta signaling depends on activation of Smad2 and Smad3 byExpand
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Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers.
INTRODUCTION Surgical simulation models are often limited by their lack of fidelity, which hinders their essential purpose, making a better surgeon. Fresh cadaveric tissue is a superior model ofExpand
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Analysis of risk factors associated with microvascular free flap failure using a multi‐institutional database
There are numerous factors that may contribute to microvascular free flap failure. Although technical issues are dominant factors, patient and clinical characteristics are also contributory. The aimExpand
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Epithelial-specific requirement of FGFR2 signaling during tooth and palate development.
Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role inExpand
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Neonatal and Infant Mandibular Distraction as an Alternative to Tracheostomy in Severe Obstructive Sleep Apnea
Context Surgical management for severe obstructive sleep apnea has been tracheostomy, which has significant morbidity. Objective To determine the efficacy of internal mandibular distraction inExpand
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