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Propeptin, a new inhibitor of prolyl endopeptidase produced by Microbispora. I. Fermentation, isolation and biological properties.
Propeptin, an inhibitor of the prolyl endopeptidase of the genus Flavobacterium competitively when Z-Gly-Pro-pNA was used as a substrate, was purified by column chromatographies on silica gel and Sephadex LH20 and high performance liquid chromatography using an ODS column.
Chloroisonicotinamide derivative induces a broad range of disease resistance in rice and tobacco.
It is suggested that NCI induces SAR by triggering signaling at the same level as or downstream of SA accumulation as do both benzo(1,2,3)thiadiazole-7-carbothioic acid S-methyl ester and 2,6-dichloroisonicotinic acid, which suggests that several common components function in disease resistance in both plant species.
Kerriamycin B inhibits protein SUMOylation
SUMO conjugation is catalyzed by a multi-step enzymatic reaction cascade similar toubiquitinylation, which has been revealed as one of the major post-translational regulatory systems in animals and other eukaryotes.
Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus
Missing links in the fumitremorgin biosynthetic pathway have been elucidated as crucial processes for the inhibitory activity of fum it Remorgin C against breast cancer resistance protein (BCRP).
Isolation and structure of phosphazomycin C.
The structure elucidation of the phosphazomycin C complex is reported, which shows that it is a mixture of two components, C 1 and C 2 .
Structure of the antifungal nucleotide antibiotic phosmidosine
The structure of phosmidosine (1), a novel proline-containing nucleotide antibiotic from Streptomyces durhameusis, active against the pathogenic fungus Botrytis cinerea, was determined by mass
Preferential suppression of delayed-type hypersensitivity by L-156,602, a C5a receptor antagonist.
In the course of our screening for in vivo immunomodulating substances in which sheep red blood cells (SRBC) and heat-killed Brucella abortus cells (thymus dependent and independent antigens,
Two Benzylated Dihydroflavonols from Cudrania tricuspidata
Two new benzylated dihydroflavonols, gericudranins D and E, were isolated from the stem bark of Cudrania tricuspidata and were shown to be significantly cytotoxic to human tumor cell lines in culture.