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Role of Semicarbazide-sensitive Amine Oxidase on Glucose Transport and GLUT4 Recruitment to the Cell Surface in Adipose Cells*
TLDR
It is proposed that SSAO activity might contribute through hydrogen peroxide production to the in vivo regulation of GLUT4 trafficking in adipose cells. Expand
Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.
TLDR
SSAO, from some sources, behaves as a cellular adhesion protein under inflammatory and it may also be involved in lipid transport, and this review considers what is known about the activities and potential functions of this hardworking protein. Expand
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent
TLDR
Results suggest that the new compounds are promising multitarget drug candidates with potential impact for Alzheimer's disease therapy, and support the dual binding site to AChE, which explains the inhibitory effect exerted on Aβ aggregation. Expand
A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain.
TLDR
In primary rat neuron cultures, the LMN cream dramatically protected against damage caused by both hydrogen peroxide and Abeta(1-42), demonstrating a potent antioxidant effect that could play a major role in the normal adult neurogenesis and, moreover, theLMN diet could have a significant effect combating the cognitive function decline during both aging and neurodegenerative diseases such as Alzheimer's disease. Expand
PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress
TLDR
The blocking of ERK5 activation by okadaic acid was observed in HeLa cells exposed to epidermal growth factors and H2O2 as well as in PC12 cells stimulated by nerve growth factor and H 2O2, suggesting that either PP1 or PP2A or both are necessary for ERK 5 activation. Expand
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
TLDR
The results indicate that ADD patients present a significant increase of cell damage through a RAGE-dependent mechanism, suggesting that AGEs may promote the generation of an oxidative stress vicious cycle, which can explain the severe progression of patients with both pathologies. Expand
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the
TLDR
It is found that, in general, and for the same substituent, amines are more potent ChE inhibitors or equipotent than the corresponding amides, showing a clear EeAChE inhibition selectivity. Expand
Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2‐imidazoline receptors in rat liver
TLDR
The main aim of this study was to assess the inhibitory effects and nature of the inhibition of imidazol(ine)/guanidine drugs on rat liver MAO‐A andMAO‐B isoforms and to compare their inhibitory potencies with their affinities for the sites labelled by [3H]‐clonidine in the same tissue. Expand
Semicarbazide-sensitive amine oxidase substrates stimulate glucose transport and inhibit lipolysis in human adipocytes.
TLDR
Results show that human adipocytes express a membrane-bound SSAO that not only readily oxidizes exogenous amines and generates H(2)O(2), but that also interplays with glucose and lipid metabolism by exerting insulin-like actions, which could bring relevant information in pathologies such as obesity or diabetes. Expand
Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung.
TLDR
The bovine lung enzyme was relatively insensitive to inhibition by cyanide, copper-chelating agents and amiloride, and narrower than reported for soluble SSAO. Expand
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