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Role of Semicarbazide-sensitive Amine Oxidase on Glucose Transport and GLUT4 Recruitment to the Cell Surface in Adipose Cells*
It is proposed that SSAO activity might contribute through hydrogen peroxide production to the in vivo regulation of GLUT4 trafficking in adipose cells.
Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent…
- Irene Bolea, J. Juárez-Jiménez, Abdelouahid Samadi
- Chemistry, BiologyJournal of medicinal chemistry
- 15 November 2011
Results suggest that the new compounds are promising multitarget drug candidates with potential impact for Alzheimer's disease therapy, and support the dual binding site to AChE, which explains the inhibitory effect exerted on Aβ aggregation.
Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung.
The bovine lung enzyme was relatively insensitive to inhibition by cyanide, copper-chelating agents and amiloride, and narrower than reported for soluble SSAO.
A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain.
In primary rat neuron cultures, the LMN cream dramatically protected against damage caused by both hydrogen peroxide and Abeta(1-42), demonstrating a potent antioxidant effect that could play a major role in the normal adult neurogenesis and, moreover, theLMN diet could have a significant effect combating the cognitive function decline during both aging and neurodegenerative diseases such as Alzheimer's disease.
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2‐imidazoline receptors in rat liver
- A. Ozaita, G. Olmos, M. Assumpció Boronat, José Miguel Lizcano, M. Unzeta, J. García-Sevilla
- Biology, ChemistryBritish journal of pharmacology
- 1 July 1997
The main aim of this study was to assess the inhibitory effects and nature of the inhibition of imidazol(ine)/guanidine drugs on rat liver MAO‐A andMAO‐B isoforms and to compare their inhibitory potencies with their affinities for the sites labelled by [3H]‐clonidine in the same tissue.
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the…