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Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres
ABSTRACT The Mre11-Rad50-Nbs1(Xrs2) complex and the Ku70-Ku80 heterodimer are thought to compete with each other for binding to DNA ends. To investigate the mechanism underlying this competition, weExpand
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Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase
The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal growth but isExpand
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TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients
The protein kinase TOR (target of rapamycin) controls several steps of ribosome biogenesis, including gene expression of rRNA and ribosomal proteins, and processing of the 35S rRNA precursor, in theExpand
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Fission Yeast Dna2 Is Required for Generation of the Telomeric Single-Strand Overhang
ABSTRACT It has been suggested that the Schizosaccharomyces pombe Rad50 (Rad50-Rad32-Nbs1) complex is required for the resection of the C-rich strand at telomere ends in taz1-d cells. However, theExpand
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Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature
Abstract. A target of rapamycin (TOR) protein is a protein kinase that exerts cellular signal transduction to regulate cell growth in response to extracellular nutrient conditions. In theExpand
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Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S. pombe, and Construction of an Overproduction System
Ergothioneine is a small, sulfur-containing metabolite (229 Da) synthesized by various species of bacteria and fungi, which can accumulate to millimolar levels in tissues or cells (e.g. erythrocytes)Expand
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A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe
Schizosaccharomyces pombe isp6+ gene encodes a vacuolar serine protease, which is specifically induced during nitrogen starvation. An isp6-disruption mutant, isp6Δ, grew normally under normalExpand
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Molecular Characterization of the Schizosaccharomyces pombe nbs1+ Gene Involved in DNA Repair and Telomere Maintenance
ABSTRACT The human MRN complex is a multisubunit nuclease that is composed of Mre11, Rad50, and Nbs1 and is involved in homologous recombination and DNA damage checkpoints. Mutations of the MRN genesExpand
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Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.
The telomere complex must allow nucleases and helicases to process chromosome ends to make them substrates for telomerase, while preventing these same activities from disrupting chromosomeExpand
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SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1Tpp1 to modulate shelterin–Stn1 interaction in fission yeast
Significance Telomeres protect DNA ends of linear eukaryotic chromosomes from degradation and fusion through the recruitment of telomerase. We previously found that SUMOylation negatively regulatesExpand
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