• Publications
  • Influence
Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors.
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, whichExpand
  • 45
1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.
1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure-activity relationship studies of 1-oxacephems led to compounds 15, which exhibited 27 nM inhibition ofExpand
  • 14
Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.
1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 1-oxacephems led to compound 34, which exhibited 6 nMExpand
  • 19
Flavin-catalyzed aerobic oxidation of sulfides and thiols with formic acid/triethylamine.
An efficient and practical catalytic method for the aerobic oxidative transformation of sulfides into sulfoxides, and thiols into disulfides with formic acid/TEA in the presence of a new, readilyExpand
  • 33
  • PDF
Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.
The present work demonstrates that the 1,3-diazetidine-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G andExpand
  • 14
Method of producing a 4-thiazolylmethyl.
A process for the production of 4-chloromethylthiazole comprising: (a) reacting 4-methylthiazole with N-chlorosuccinimide in chlorobenzene in the presence of 2, 2-azobisisobutyronitrile and (b)Expand
Process for the preparation of derivatives of trans-4-amino-cyclohexanecarboxylic acid-1.
A process for the preparation of a compound of formula: where R 1 and R 2 are each independently a C1 to C6 linear or branched, which comprises reacting a compound of formula: wherein each symbol isExpand
...
1
2
...