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Centrosome positioning and directionality of cell movements.
In several cell types, an intriguing correlation exists between the position of the centrosome and the direction of cell movement: the centrosome is located behind the leading edge, suggesting thatExpand
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Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells
Chronic myeloid leukemia (CML) is characterized by the clonal expansion of hematopoietic stem cells (HSCs). Without effective treatment, individuals in the indolent, chronic phase (CP) of CML undergoExpand
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Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
Multiple myeloma (MM) is incurable, mainly because of cell adhesion-mediated drug resistance (CAM-DR). In this study, we performed functional screening using short hairpin RNA (shRNA) to define theExpand
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Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene.
We recently reported that a germ-line insertion in the rat homologue of the human tuberous sclerosis gene (TSC2) gives rise to dominantly inherited cancer in the Eker rat model. In this study, weExpand
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Centrosomes, microtubules and cell migration.
Directed cell movement is an immensely complex process that depends on the co-operative interaction of numerous cellular components. Work over the past three decades has suggested that microtubulesExpand
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Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc.
By NIH3T3 transfection assay in conjunction with in vitro transient neomycin selection, activated c-H-ras-1 oncogenes were detected in two squamous cell carcinoma cell lines, ZA and HOC-313, newlyExpand
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Isolation of nucleation-competent centrosomes from Dictyostelium discoideum.
The centrosome of Dictyostelium discoideum is a box-shaped, layered core structure surrounded by a corona which is made up of dense nodules embedded in amorphous material. It is also known asExpand
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K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
K-ras gene mutations in early colorectal cancer were detected by two-step sensitive polymerase chain reaction (PCR) and enzyme digestion method. Early colorectal cancer was classified into flatExpand
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Processing of CD109 by furin and its role in the regulation of TGF-β signaling
CD109 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein, whose expression is upregulated in squamous cell carcinomas of the lung, esophagus, uterus and oral cavity. CD109 negativelyExpand
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Antitumor Effect of β2-Microglobulin in Leukemic Cell-bearing Mice via Apoptosis-inducing Activity Activation of Caspase-3 and Nuclear Factor-κB
We have reported previously that β2-microglobulin (β2m) induces apoptosis in leukemic cells in vitro , and that an interaction between β2m and HLA class I antigen induces apoptosis. Here we examinedExpand
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