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Changes in extracellular concentration of amino acids in the hippocampus during cerebral ischemia in stroke-prone SHR, stroke-resistant SHR and normotensive rats
TLDR
The results suggest that the massive glutamate release during cerebral ischemia of SHRSP might be related with severe neuronal cell injury. Expand
Vasodilatation Induced by Pinacidil in Dogs. Comparison with Hydralazine and Nifedipine
TLDR
It may be concluded that pinacidil produces vasodilatation due to interference with the transmembrane influx of Ca2+ into smooth muscle evoked by receptor stimulation but not that due to inhibition in the Ca2- influx associated with K+-induced membrane depolarization. Expand
Spatial changes of [Ca2+]i and contraction caused by phorbol esters in vascular smooth muscle cells.
TLDR
The results suggest that PKC activation induces cellular contractions through two distinct mechanisms, one dependent on and another independent of the [Ca2+]i increase. Expand
A novel non‐peptide endothelin antagonist isolated from bayberry, Myrica cerifera
TLDR
A potent non‐peptide ET receptor antagonist, myrireron caffeoyl ester (50–235), was isolated from the bayberry and can be useful for studying the physiological role of endothelin and exploring its role in various diseases. Expand
Antagonistic actions of S-145 on vascular and platelet thromboxane A2 receptors.
We studied the actions of a potent thromboxane A2/prostaglandin in H2 (TP) receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo [2.2.1]hept-2-exo-yl]heptenoic acid (S-145) onExpand
Pharmacological studies on a new antihypertensive agent, S-2150, a benzothiazepine derivative: 3. Hypotensive and antimyocardial-stunning effects in dogs.
TLDR
The results suggest that S-2150 is a favorable hypotensive agent for hypertensive patients with ischemic heart disease, and blockage of both Ca2+ channels and alpha 1-adrenoceptors by S- 2150 seems to lead to cardiovascular effects different from those of diltiazem. Expand
[Pharmacological studies on pinacidil, a new antihypertensive agent. 2. Studies on the hypotensive mechanism of pinacidil].
TLDR
The results suggest that the hypotensive effect of PND is more closely associated with the inhibition of Ca2+ influx caused by the receptor activation ofCa2+ release from intracellular storage sites than membrane potential-dependent Ca2-dependent influx. Expand
INTRINSIC β-SYMPATHOMIMETIC ACTIVITY OF DILEVALOL, R, RISOMER OF LABETALOL
The potency and selectivity of the intrinsic β-sympathomimetic activity (ISA) of dilevalol were studied with isolated guinea-pig trachea and pithed rat. This drug relaxed the contracture of isolatedExpand
Comparison of vascular and platelet thromboxane A2/prostaglandin H2 receptors in the pig.
TLDR
The binding sites in the vascular and platelet receptors seem to be the same or quite similar, but there seems to be different mechanism(s) leading the agonistic binding signal to final responses. Expand
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