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Comparison of the effect of endothelium on the responses to sumatriptan in rabbit isolated iliac, mesenteric and carotid arteries.
  • O. Yildiz, M. Tuncer
  • Biology, Medicine
    Archives internationales de pharmacodynamie et de…
  • 1 September 1994
TLDR
The results suggest that sumatriptan-induced contractions of the rabbit iliac, but not mesenteric artery, were depressed by itself through the release of nitric oxide upon stimulation of 5-HT1-like receptors located on the endothelium, whereas neither on vascular smooth muscle nor on endothelia, 5- HT1- like receptors were present in the rabbit carotid artery.
5-HT1-like receptor-mediated contraction in the human internal mammary artery.
TLDR
The 5-hydroxytryptamine (5-HT) receptors mediating vasoconstriction in the human internal mammary artery (IMA) were characterized by suspending segments of the IMA in an organ bath and exposed to 5-HT and sumatriptan.
Role of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive rats.
TLDR
The isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin when compared with normotensive Wistar-Kyoto (WKY) rats.
Cyclosporin A and Cremophor-EL augment renal vascular responses to various agonists and nerve stimulation.
  • E. Yariş, M. Tuncer
  • Biology, Medicine
    Archives internationales de pharmacodynamie et de…
  • 1 May 1995
TLDR
The results suggest that cyclosporin A may exert a directaction on the vasculature rather than an action on the vascular adrenergic neurotransmission of the rabbit kidney.
Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery.
TLDR
The results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA.
Actions of cyclosporin A preparation and Cremophor-EL in rabbit mesenteric artery and thoracic aorta in vitro.
TLDR
The results indicate that Cremophor-EL may contribute to the inhibitory action of cyclosporin A preparation on acetylcholine-induced endothelium-dependent relaxation in the superior mesenteric artery, but is fully responsible for the smooth-muscle-contracting effect and the potentiation of phenylephrine-induced contraction in both arteries.
The subtype of serotonin (5-HT) receptors in the rat pulmonary artery.
TLDR
The results suggest that 5-HT receptors in rat main pulmonary artery are of the5-HT2 subtype, and some alpha-agonists induced a marked contraction of ring segments of the rat pulmonary artery.
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