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The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis
TOR controls translation initiation and early G1 progression in yeast.
- N. Barbet, U. Schneider, S. B. Helliwell, I. Stansfield, M. Tuite, M. Hall
- BiologyMolecular biology of the cell
It is proposed that the TORs, two related phosphatidylinositol kinase homologues, are part of a novel signaling pathway that activates eIF-4E-dependent protein synthesis and, thereby, G1 progression in response to nutrient availability and may constitute a checkpoint that prevents early G 1 progression and growth in the absence of nutrients.
Fungal Adenylyl Cyclase Integrates CO2 Sensing with cAMP Signaling and Virulence
Protein disulphide isomerase: building bridges in protein folding.
Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI(+)] of Saccharomyces cerevisiae.
- S. Eaglestone, L. Ruddock, B. Cox, M. Tuite
- BiologyProceedings of the National Academy of Sciences…
- 4 January 2000
It is proposed that GuHCl inhibits a critical event in the propagation of the prion conformer and demonstrated that the kinetics of curing by Gu HCl fit a random segregation model whereby the heritable [PSI(+)] element is diluted from a culture, after the total inhibition of prion replication by GuH Cl.
The elimination of the yeast [PSI+] prion by guanidine hydrochloride is the result of Hsp104 inactivation
GdnHCl inhibits two different Hsp104‐dependent cellular processes, namely the acquisition of thermotolerance and the refolding of thermally denatured luciferase, which leads to a block in the replication of [PSI+] seeds.
Dissection and Design of Yeast Prions
Novel artificial prions are designed by fusing the replication element of Sup35p to aggregation-prone sequences from other proteins, including pathogenically expanded polyglutamine, to explain why although Q/N-rich proteins are relatively common, few form heritable aggregates.
Post-transcriptional gene regulatory mechanisms in eukaryotes: an overview.
In this short review, selected examples of post-transcriptional gene regulatory mechanisms operating in both lower and higher eukaryotes will be used to highlight the plethora of such mechanisms already identified.
Agents that cause a high frequency of genetic change from [psi+] to [psi-] in Saccharomyces cerevisiae.
In this study, the following agents have been shown to induce the same genetic change: guanidine hydrochloride at 1 mM, dimethyl sulfoxide at 2.5% v/v and ethanol or methanol at 10% v-v.
Analysis of the generation and segregation of propagons: entities that propagate the [PSI+] prion in yeast.
It is shown that at low propagon number there is a bias toward retention of propagons in mother cells and that production of new propagons is very rapid when cells with depleted numbers of propagon are rescued into normal growth medium.