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Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae
TLDR
The results on the apg mutants suggest that autophagy via autophagic bodies is indispensable for protein degradation in the vacuoles under starvation conditions, and that at least 15 APG genes are involved inAutophagy in yeast. Expand
Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae.
TLDR
It is shown that the APG1 gene, involved in the autophagic process in yeast, encodes a novel type of Ser/Thr protein kinase, suggesting that homologous molecular mechanisms, conserved from unicellular to multicellular organisms, are involved in dynamic membrane flow. Expand
13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors.
TLDR
High levels of mRNA levels of cellular retinoic acid-binding protein II, which is supposed to regulate the concentration of intracellular all-trans retinoid acid, rapidly increased under all- trans retinoi acid treatment, whereas the 13-cis retinooic acid effect was markedly weaker and delayed. Expand
Structural and functional analysis of a novel coiled-coil protein involved in Ypt6 GTPase-regulated protein transport in yeast.
TLDR
The results of this study suggest that Sys3p, like Ypt6p, acts in vesicular transport (presumably at a vesicle-docking stage) between an endosomal compartment and the most distal Golgi compartment. Expand
Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p.
TLDR
Four multicopy suppressors are isolated that can complement the temperature-sensitive growth phenotype of the ypt6 null mutant and enhance defects in vacuolar protein sorting and in cell growth in Saccharomyces cerevisiae mutants. Expand
Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1)
TLDR
It is demonstrated that dephosphorylation of specific sites phosphorylated by JNK is mediated by Neurabin II, which recruits the phosphatase PP1, which plays an important role in normal neuronal migration. Expand
Identification of neurabin II as a novel doublecortin interacting protein
TLDR
Using a yeast two-hybrid screen with Dcx as bait, neurabin II/spinophilin is isolated, an F-actin binding protein known to play a role in dendritic spine formation and Immunoprecipitation experiments with brain extracts show that neurabin I and DcX interact in vivo. Expand
Differentiation and apoptosis in human immortalized sebocytes.
TLDR
SZ95 sebocytes in vitro undergo apoptosis, which can be enhanced by the terminal differentiation inductor arachidonic acid or by staurosporine and leads to cell death. Expand
Doublecortin Association with Actin Filaments Is Regulated by Neurabin II*
TLDR
It is demonstrated that Dcx co-sediments with actin filaments (F-actin), and using light and electron microscopy and spin down assays, it is shown that D cx induces bundling and cross-linking of microtubules and F- actin in vitro. Expand
Neurabin II mediates doublecortin-dephosphorylation on actin filaments.
TLDR
It is suggested that a dynamic regulation of Dcx mediated by neurabin II regulates the translocation of D cx from F-actin to microtubules and vice versa. Expand
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