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Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells*
TLDR
It is concluded that NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress and further implies a novel application of the vitamin to treat diseases such as those associated with the depletion of cellular NAD pools. Expand
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.
TLDR
The discovery of two new ARF-like genes, ARF 5 and 6, encoding proteins of 180 and 175 amino acids, respectively, were identified, which contain consensus sequences believed to be involved in guanine nucleotide binding and GTP hydrolysis. Expand
The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
TLDR
Using a liquid chromatographic-tandem mass spectrometric method, the amounts of NMN, NAMN, NAD(+), and 5'AMP present in mouse erythrocytes are measured, in a single analysis, and this is the first report of a direct determination of the amounts in any type of cell. Expand
Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma
TLDR
It is concluded that visfatin does not participate in NMN formation under the extracellular milieus, and the concept of NAMPT-mediated systemic NAD biosynthesis is not supported. Expand
Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.
TLDR
This study indicates that the synergistic augmentation of the cytotoxicity by LY294002 occurs specifically with antimicrotubule agents, at least partially through an increase in caspase 3-dependent apoptosis, and suggests that inhibitors of the PI3K/Akt pathway in combination with antim Microtubule Agents may induce cell death effectively and be a potent modality to treat patients with malignant gliomas. Expand
Molecular Identification of Human Glutamine- and Ammonia-dependent NAD Synthetases
TLDR
The results indicate that the carbon-nitrogen hydrolase domain is the functional domain of NAD synthetase to make use of glutamine as an amide donor in NAD synthesis, and glutamine-dependent NAD Synthetase may be classified as a possible glutamine amidase in the nitrilase family. Expand
ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain.
TLDR
Recombinant ARD1 or the ARF domain of ARD 1, which lacks the 15 amino acids corresponding to the amino-terminal regions of ARFs stimulated, in a GTP-dependent manner, cholera toxin ADP-ribosyltransferase activity in the presence of 0.3% Tween 20. Expand
ADP‐ribosylation of tuftsin suppresses its receptor‐binding capacity and phagocytosis‐stimulating activity to murine peritoneal macrophages
TLDR
The ADP‐ribosylation of tuftsin apparently decreases its biological activity and ADP-ribosYLation may possibly be involved in inflammatory processes through alterations in tuft sin activity. Expand
FR-167653, a selective p38 MAPK inhibitor, exerts salutary effect on liver cirrhosis through downregulation of Runx2
TLDR
The salutary effect of FR, a selective p38 inhibitor, in a carbon tetrachloride-induced rat cirrhotic model exerted a significant beneficial effect and could be partially attributable to an inhibition of the Smad4/p38/Runx2 axis in the Cirrhotic liver. Expand
Glutamic Acid 207 in Rodent T-cell RT6 Antigens Is Essential for Arginine-specific ADP-ribosylation*
A rat T-cell antigen RT6.1 catalyzes NAD glycohydrolysis but not ADP-ribose transfer, even though the antigen has significant amino acid identity with eucaryotic arginine-specificExpand
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