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Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.
OBJECTIVE Ghrelin is a new gastric hormone that has been identified as an endogenous ligand for the growth hormone (GH) secretagogue receptor subtype 1a (GHS-R1a). Ghrelin administration however notExpand
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Role of ghrelin polymorphisms in obesity based on three different studies.
OBJECTIVE Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), andExpand
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Glucagon regulation of energy metabolism
Glucagon has long been known as a counter-regulatory hormone to insulin of fundamental importance to glucose homeostasis. Its prominent ability to stimulate glycogenolysis and gluconeogenesis, hasExpand
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Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats.
OBJECTIVE The novel gastric hormone ghrelin has recently been identified as an important modulator of energy homeostasis. Leptin-responsive hypothalamic neuropeptide Y/Agouti-related protein neuronsExpand
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Influence of Acute Exposure to High Altitude on Basal and Postprandial Plasma Levels of Gastroenteropancreatic Peptides
Acute mountain sickness (AMS) is characterized by headache often accompanied by gastrointestinal complaints that vary from anorexia through nausea to vomiting. The aim of this study was toExpand
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PYY3‐36 as an anti‐obesity drug target
The neuropeptide Y (NPY)/peptide YY (PYY) system has been implicated in the physiology of obesity for several decades. More recently, Batterham et al. 2002 ignited enormous interest in PYY3‐36, anExpand
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Ghrelin and motilin: two sides of one coin?
We would like to emphasize structural and effect-related similarities between the gastrointestinal hormone motilin, the recently discovered agent motilin-related peptide and a novel endogenous ligandExpand
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Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5
Objective Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupledExpand
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Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay.
Panels of monoclonal antibodies (mAbs) were raised against recombinant human leptin and the recombinant human soluble leptin receptor. Using these mAbs, we established a ligand-mediatedExpand
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