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Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.
OBJECTIVE Ghrelin is a new gastric hormone that has been identified as an endogenous ligand for the growth hormone (GH) secretagogue receptor subtype 1a (GHS-R1a). Ghrelin administration however not… Expand
Role of ghrelin polymorphisms in obesity based on three different studies.
OBJECTIVE Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and… Expand
Glucagon regulation of energy metabolism
- K. Heppner, K. Habegger, Jonathan Day, P. Pfluger, M. Tschöp
- Biology, Medicine
- Physiology & Behavior
- 14 July 2010
Glucagon has long been known as a counter-regulatory hormone to insulin of fundamental importance to glucose homeostasis. Its prominent ability to stimulate glycogenolysis and gluconeogenesis, has… Expand
Raised leptin concentrations at high altitude associated with loss of appetite
Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats.
OBJECTIVE The novel gastric hormone ghrelin has recently been identified as an important modulator of energy homeostasis. Leptin-responsive hypothalamic neuropeptide Y/Agouti-related protein neurons… Expand
Influence of Acute Exposure to High Altitude on Basal and Postprandial Plasma Levels of Gastroenteropancreatic Peptides
Acute mountain sickness (AMS) is characterized by headache often accompanied by gastrointestinal complaints that vary from anorexia through nausea to vomiting. The aim of this study was to… Expand
PYY3‐36 as an anti‐obesity drug target
- M. M. Boggiano, P. Chandler, +34 authors M. Tschöp
- Obesity reviews : an official journal of the…
- 1 November 2005
The neuropeptide Y (NPY)/peptide YY (PYY) system has been implicated in the physiology of obesity for several decades. More recently, Batterham et al. 2002 ignited enormous interest in PYY3‐36, an… Expand
Ghrelin and motilin: two sides of one coin?
We would like to emphasize structural and effect-related similarities between the gastrointestinal hormone motilin, the recently discovered agent motilin-related peptide and a novel endogenous ligand… Expand
Inverse Agonistic Action of 3-Iodothyronamine at the Human Trace Amine-Associated Receptor 5
- Juliane Dinter, Jessica Mühlhaus, +10 authors H. Biebermann
- Biology, Medicine
- PloS one
- 23 February 2015
Objective Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled… Expand
Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay.
- Z. Wu, M. Bidlingmaier, +4 authors C. Strasburger
- Medicine, Biology
- The Journal of clinical endocrinology and…
- 1 June 2002
Panels of monoclonal antibodies (mAbs) were raised against recombinant human leptin and the recombinant human soluble leptin receptor. Using these mAbs, we established a ligand-mediated… Expand