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Identification of Sef, a novel modulator of FGF signalling
TLDR
The identification of a novel modulator of FGF signal transduction, sef, isolated from a zebrafish embryo library through an in situ hybridization screen is reported, suggesting that Sef is required to limit FGF signalling during development. Expand
Requirement for endoderm and FGF3 in ventral head skeleton formation.
TLDR
It is revealed for the first time that the endoderm provides differential cues along the anteroposterior axis to control ventral head skeleton development and it is demonstrated that this function is mediated in part by Fgf3. Expand
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
TLDR
A temporal role for Dusp6 in restricting cardiac progenitors and controlling heart organ size was uncovered with BCI treatment at varying developmental stages, highlighting the power of in vivo zebrafish chemical screens to identify novel compounds targeting D Susp6, a component of the FGF signaling pathway that has eluded traditional high-throughput in vitro screens. Expand
Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway
TLDR
The discovery of a subset of conserved FGF target genes that encode feedback regulators of F GF signaling itself is discussed, suggesting that precise adjustment of FGF signaling is critical in development. Expand
Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development
TLDR
It is demonstrated that Dvl3 is required for cardiac outflow tract development and its importance in the PCP pathway during neurulation and cochlea development and several developmental processes in which the three Dvls are functionally redundant are established. Expand
Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
TLDR
The generation of transgenic reporter zebrafish lines has allowed direct visualization of FGF signalling within the developing embryo and provided a tool to screen for specific compounds that can distinguish between two conserved members of the RTK family. Expand
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.
TLDR
It is suggested that derepression of Wnt signaling by targeting secreted Wnt antagonists in osteoblasts may increase susceptibility to osteosarcoma. Expand
A role for MKP3 in axial patterning of the zebrafish embryo
TLDR
G Gain- and loss-of-function studies reveal that MKP3 is required to limit the extent of FGF/RAS/MAPK signaling in the early embryo, and that disturbing this inhibitory pathway disrupts dorsoventral patterning at the onset of gastrulation. Expand
Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
TLDR
DUSP6 is a potential intervention target for restoring T cell responses in the elderly, which may augment the effectiveness of vaccination. Expand
Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity.
TLDR
It is shown that an alternative splicing mechanism generates an isoform of human Sef, hSef-b, which unlike the previously reported Sef-a, which is a cytosolic protein, display a restricted pattern of expression in human tissues and expands the Sef feedback inhibition repertoire of RTK signaling. Expand
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