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Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study
Polyunsaturated fatty acids (PUFA) have a role in many physiological processes, including energy production, modulation of inflammation, and maintenance of cell membrane integrity. High plasma PUFA… Expand
Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids.
BACKGROUND The sum of eicosapentaenoic acid (EPA, 20:5 omega3) and docosahexaenoic acid (DHA, 22:6 omega3) in erythrocyte membranes, termed the omega-3 index, can indicate suboptimal intake of… Expand
Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
BACKGROUND Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective… Expand
Dyslipidemia Prevalence, Treatment, and Control in the Multi-Ethnic Study of Atherosclerosis (MESA): Gender, Ethnicity, and Coronary Artery Calcium
Background— To assess the implementation challenge facing the Third Report of the Adult Treatment Panel (ATP III) of the National Cholesterol Education Program, we determined the prevalence,… Expand
The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial.
IMPORTANCE Chronic periodontitis, a destructive inflammatory disorder of the supporting structures of the teeth, is prevalent in patients with diabetes. Limited evidence suggests that periodontal… Expand
Mendelian randomization of blood lipids for coronary heart disease
Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian… Expand
trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).
- D. Mozaffarian, Marcia C de Oliveira Otto, +5 authors J. Nettleton
- The American journal of clinical nutrition
- 1 April 2013
BACKGROUND Dairy consumption is linked to a lower risk of type 2 diabetes, but constituents responsible for this relation are not established. Emerging evidence suggests that trans-palmitoleate… Expand
Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis
Using ∼60,000 SNPs selected for minimal linkage disequilibrium, we perform population structure analysis of 1,374 unrelated Hispanic individuals from the Multi-Ethnic Study of Atherosclerosis (MESA),… Expand
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
- F. Asselbergs, Y. Guo, +167 authors F. Drenos
- Biology, Medicine
- American journal of human genetics
- 2 November 2012
Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as… Expand
ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)
- T. Ohira, M. Cushman, +5 authors A. Folsom
- Journal of thrombosis and haemostasis : JTH
- 1 July 2007
Summary. Background: Numerous case–control studies have reported higher prevalence of non‐O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect… Expand