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Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the most common amino acidExpand
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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the Parkin E3 ligase byExpand
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Screening of DUB activity and specificity by MALDI-TOF mass spectrometry
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and areExpand
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The phagosomal proteome in interferon-gamma-activated macrophages.
The ability of macrophages to clear pathogens and elicit a sustained immune response is regulated by various cytokines, including interferon-gamma (IFN-gamma). To investigate the molecular mechanismsExpand
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Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons.
The anaerobic metabolism of the opportunistic pathogen Pseudomonas aeruginosa is important for growth and biofilm formation during persistent infections. The two Fnr-type transcription factors AnrExpand
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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
Summary Clearance of misfolded and aggregated proteins is central to cell survival. Here, we describe a new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factorExpand
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Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export‐competent RNP
The eukaryotic translation initiation factor 4E (eIF4E) controls gene expression through its effects on mRNA export and cap‐dependent translation, both of which contribute to its oncogenic potential.Expand
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Comparative proteome analysis of secretory proteins from pathogenic and nonpathogenic Listeria species
Extracellular proteins of bacterial pathogens play a crucial role in the infection of the host. Here we present the first comprehensive validation of the secretory subproteome of the Gram positiveExpand
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Molecular characterization of the evolution of phagosomes
Amoeba use phagocytosis to internalize bacteria as a source of nutrients, whereas multicellular organisms utilize this process as a defense mechanism to kill microbes and, in vertebrates, initiate aExpand
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Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
During infection of their hosts, Gram‐positive bac‐teria express surface proteins that serve multiple biological functions. Surface proteins harbouring a C‐terminal sorting signal with an LPXTG motifExpand
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