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Adaptive radiation in a heterogeneous environment
Successive adaptive radiations have played a pivotal role in the evolution of biological diversity. The effects of adaptive radiation are often seen, but the underlying causes are difficult toExpand
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Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
We followed evolutionary change in 12 populations of Escherichia coli propagated for 10,000 generations in identical environments. Both morphology (cell size) and fitness (measured in competitionExpand
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Experimental tests of the roles of adaptation, chance, and history in evolution.
The contributions of adaptation, chance, and history to the evolution of fitness and cell size were measured in two separate experiments using bacteria. In both experiments, populations propagated inExpand
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Experimental evolution of multicellularity
Multicellularity was one of the most significant innovations in the history of life, but its initial evolution remains poorly understood. Using experimental evolution, we show that key steps in thisExpand
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The Prisoner's Dilemma and polymorphism in yeast SUC genes
The SUC multigene family of the single–celled yeast Saccharomyces cerevisiae is polymorphic, with genes varying both in number and activity. All of the genes encode invertase, an enzyme that isExpand
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Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles
Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastableExpand
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Detecting linkage disequilibrium in bacterial populations.
The distribution of the number of pairwise differences calculated from comparisons between n haploid genomes has frequently been used as a starting point for testing the hypothesis of linkageExpand
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Adaptive divergence in experimental populations of Pseudomonas fluorescens. I. Genetic and phenotypic bases of wrinkly spreader fitness.
A central feature of all adaptive radiations is morphological divergence, but the phenotypic innovations that are responsible are rarely known. When selected in a spatially structured environment,Expand
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Hybrid Speciation in Experimental Populations of Yeast
Most models of speciation require gradual change and geographic or ecological isolation for new species to arise. Homoploid hybrid speciation occurred readily between Saccharomyces cerevisiae andExpand
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Long-term experimental evolution in Escherichia coli. IV. Targets of selection and the specificity of adaptation.
This study investigates the physiological manifestation of adaptive evolutionary change in 12 replicate populations of Escherichia coli that were propagated for 2000 generations in a glucose-limitedExpand
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