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Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: Phospholipase A2 and L-amino acid oxidase.
TLDR
The whole venom as well as the l-amino acid oxidase from Bothrops marajoensis was able to inhibit the growth of several microorganisms, including S. aureus, Candida albicans, Pseudomonas aeruginosa, and Leishmania sp. Expand
Isolation of a new L-amino acid oxidase from Crotalus durissus cascavella venom.
TLDR
Electron microscopy assessments of both bacterial strains suggest that the hydrogen peroxide produced by LAO induce bacterial membrane rupture and consequently loss of cytoplasmatic content, suggesting that the production of H2O2 is involved in subsequent activation of inflammatory enzymes, such as thromboxane. Expand
Structural basis for low catalytic activity in Lys49 phospholipases A2--a hypothesis: the crystal structure of piratoxin II complexed to fatty acid.
TLDR
The crystal structure of one such Lys49 PLA2, piratoxin-II, is described, in which a fatty acid molecule is observed within the substrate channel, suggesting that such toxins may be active enzymes in which catalysis is interrupted at the stage of substrate release. Expand
Participation of Na(+) channels in the potentiation by Tityus serrulatus alpha-toxin TsTx-V of glucose-induced electrical activity and insulin secretion in rodent islet beta-cells.
TLDR
The construction of a three-dimensional model for TsTx-V revealed a conserved core containing an alpha-helix and three beta-strands, with minor differences when compared with toxins from other scorpion venoms. Expand
A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogenic activity.
TLDR
M-VI was devoid of phospholipase A2 (PLA2) activity on egg yolk, but could induce drastic necrosis on skeletal muscle fibres as well as rapid and transient edema on the rat paw, and revealed high homology with other Lys 49 PLA2-like myotoxins from other bothropic venoms. Expand
A trypsin inhibitor from Peltophorum dubium seeds active against pest proteases and its effect on the survival of Anagasta kuehniella (Lepidoptera: Pyralidae).
TLDR
The action of the P. dubiumtrypsin inhibitor (PDTI) on A. kuehniella may involve inhibition of the trypsin-like activity present in the larval midgut, resistance of the inhibitor to digestion byMidgut enzymes and bovine trypsins, and association of the inhibitors with a chitin column and chitinous structures in the peritrophic membrane and/or midguts of the insect. Expand
Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins.
TLDR
Comparing Ts1 to weak beta-toxins from Centruroides sculpturatus Ewing reveals that a number of basic amino acid residues located on the face of the molecule opposite to the binding surface may account for the high toxicity of Ts1. Expand
Purification and characterization of an N-acetylglucosamine-binding lectin from Koelreuteria paniculata seeds and its effect on the larval development of Callosobruchus maculatus (Coleoptera:
TLDR
The transformation of genes coding for this lectin could be useful in the development of insect resistance in important agricultural crops. Expand
Renal effects and vascular reactivity induced by Tityus serrulatus venom.
TLDR
Tityus serrulatus venom affects renal haemodynamics probably by a direct vasoconstrictor action leading to decreased renal flow and Tubular transport was not affected during the whole experimental period. Expand
Purification and biological effects of Araucaria angustifolia (Araucariaceae) seed lectin.
TLDR
AaL, intravenously injected into rats, showed anti-inflammatory effect, via carbohydrate site interaction, in the models of paw edema and peritonitis and can be used as a tool for studying bacterial infections and inflammatory processes. Expand
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