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Transient Receptor Potential Vanilloid 4–Mediated Disruption of the Alveolar Septal Barrier: A Novel Mechanism of Acute Lung Injury
Disruption of the alveolar septal barrier leads to acute lung injury, patchy alveolar flooding, and hypoxemia. Although calcium entry into endothelial cells is critical for loss of barrier integrity,Expand
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TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating the permeability increase in response to high peak inflation pressureExpand
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An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
Transient receptor potential vanilloid 4 (TRPV4) channels are expressed in human heart failure lungs, which can be blocked to prevent and resolve heart failure–induced pulmonary edema. Ion ChannelExpand
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Structure and composition of pulmonary arteries, capillaries, and veins.
  • M. Townsley
  • Medicine, Biology
  • Comprehensive Physiology
  • 2012
The pulmonary vasculature comprises three anatomic compartments connected in series: the arterial tree, an extensive capillary bed, and the venular tree. Although, in general, this vasculature isExpand
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Evaluation of lung injury in rats and mice.
Lung injury is a broad descriptor that can be applied to conditions ranging from mild interstitial edema without cellular injury to massive and fatal destruction of the lung. This review addressesExpand
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Regulation of tissue oxygenation
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TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.
We have previously implicated calcium entry through stretch-activated cation channels in initiating the acute pulmonary vascular permeability increase in response to high peak inflation pressureExpand
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Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
Little information is available regarding the vasoactive effects of epoxyeicosatrienoic acids (EETs) in the lung. We demonstrate that 5, 6-, 8,9-, 11,12-, and 14,15-EETs contract pressurized rabbitExpand
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Role of MMP2 and MMP9 in TRPV4-induced lung injury.
Ca(2+) entry through transient receptor potential vanilloid 4 (TRPV4) results in swelling, blebbing, and detachment of the epithelium and capillary endothelium in the intact lung. Subsequently,Expand
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Increased microvascular permeability in dog lungs due to high peak airway pressures.
The effect of peak airway pressure (Paw) on vascular permeability and the "safety factor" against edema formation was determined in isolated blood-perfused lower lobes of dog lungs. MicrovascularExpand
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