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Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate. Here, we report that Myc controls transcription of the lactate transporter
Therapeutics , Targets , and Chemical Biology Blocking Lactate Export by Inhibiting the Myc Target MCT 1 Disables Glycolysis and Glutathione Synthesis
TLDR
It is reported that Myc controls transcription of the lactate transporter SLC16A1/MCT1 and that elevated MCT1 levels are manifest in premalignant and neoplastic Em-Myc transgenic B cells and in human malignancies with MYC or MYCN involvement.
Synthesis of syn and anti 1,4-diols by copper-catalyzed boration of allylic epoxides.
The regio- and diastereoselective Cu(I)-catalyzed boration of allylic epoxides offers a new approach for the diastereoselective synthesis of anti and syn 1,4-diols.
para‐Quinone Methide: a New Player in Asymmetric Catalysis
This is the accepted version of the following article: Parra, A. and Tortosa, M. (2015), para-Quinone Methide: a New Player in Asymmetric Catalysis. ChemCatChem, 7: 1524–1526, which has been
Copper-Catalyzed Borylative Aromatization of p-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates
TLDR
It is established that DM-Segphos copper(I) complexes are efficient catalysts for the enantioselective borylation of para-quinone methides, with enantiomeric ratios up to 96:4, using a commercially available chiral phosphine.
Copper(I)-catalyzed formal carboboration of alkynes: synthesis of tri- and tetrasubstituted vinylboronates.
The first copper-catalyzed formal carboboration of alkynes, in which a C-B bond and a C-C bond are created in a single catalytic cycle, is presented. The reaction proceeds with high regioselectivity
Copper-catalyzed diastereo- and enantioselective desymmetrization of cyclopropenes: synthesis of cyclopropylboronates.
TLDR
A novel Cu-catalyzed diastereo- and enantioselective desymmetrization ofcyclopropenes to afford nonracemic cyclopropylboronates is described and the potential of the approach for the synthesis of functionalized cyclopopropanes is demonstrated.
Update 1 of: α,β-Diamino acids: biological significance and synthetic approaches.
TLDR
The aim of this article will be to provide a deep and general view of the existing methodology for the synthesis of aliphatic R, or 2,3-diamino acids and their simple derivatives, esters, and other interesting applications found in the existing literature.
Regio- and Stereospecific Copper-Catalyzed Substitution Reaction of Propargylic Ammonium Salts with Aryl Grignard Reagents.
TLDR
A copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents is developed that is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance.
Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach.
TLDR
The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported, which constitutes the first report of an enantiOSElective desymmetrization of meso-cyclobutenes to prepare chiral cyclobUTanes.
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