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Attachment of coxsackievirus B3 variants to various cell lines: mapping of phenotypic differences to capsid protein VP1.
Results suggest that the mutated amino acid residues in VP1 are involved in receptor recognition/binding in coxsackievirus B3 Nancy P and the hybrid virus in various nonpermissive rodent cell lines indicates that cell surface molecules other than CAR and DAF may be involved in attachment of this variant to cell surfaces. Expand
Replication and persistence of coxsackieviruses B3 in human fibroblasts.
A replication of Coxsackievirus B3 (CVB3) in diploid human fibroblasts is demonstrated that is dependent on the virus strain as well as on the cell line involved, and a carrier state of CVB3 Nancy strains over 16 cell passages is observed. Expand
Streptovirudins, new antibiotics with antibacterial and antiviral activity. II. Isolation, chemical characterization and biological activity of streptovirudins A1, A2, B1, B2, C1, C2, D1, and D2.
The streptovirudins are chemically and biologically related to each other and appear to be a new family of antibiotics exhibiting activity against a variety of Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses. Expand
Expression and secretion of interferon-alpha 1 by Streptomyces lividans: use of staphylokinase signals and amplification of a neo gene.
A gene coding for mature human interferon, IFN-alpha 1, fused to the expression and secretion signals of a staphylokinase gene (sak) derived from Staphylococcus aureus phage 42D, was inserted intoExpand
Permissiveness of human embryonal fibroblasts for coxsackieviruses B3. Investigations on virus genetic markers in vitro and localization of virus receptor distribution by immunogold replica technique.
Differences in adsorption of the CVB3 strains to two human fibroblast lines as well as to HeLa cells corresponded well with the virological results, underline that even in vitro in human cell lines of different origin changes in distribution, quantity and quality of receptors were demonstrable forming the base for the various virus sensitivity. Expand
The antiviral activity of dipyridamole.
Dipyridamole, a coronary vasodilatator, was found to possess antiviral activity against representatives of different families, and significantly inhibited the yield of members of the viral families Picornaviridae, Togaviraceae, Orthomyxovir Families, ParamyxovIRidae, Herpetoviridae and Poxviridae. Expand
Dipyridamole, an inhibitor of mengovirus replication in FL and L cells.
Dipyridamole showed an antiviral activity aganinst mengovirus in FL cells using the agar diffusion plaque inhibition test, plaque reduction test, tube titration test, and virus yield test after one replication cycle and the inhibitory action was also confirmed in L cells. Expand
Mode of Action In Vitro Against Mengovirus of Substituted 5-Amino-4-Cyanopyrazoles
Substituted amino pyrazoles were found to exhibit plaque reduction and inhibition of the cytopathic effect of mengovirus on FL cells. Their antiviral activity was not caused by a virucidal effect orExpand