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- Publications
- Influence
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
- N. Aceto, A. Bardia, +17 authors S. Maheswaran
- Biology, Medicine
- Cell
- 28 August 2014
Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammary… Expand
Isolation of rare circulating tumour cells in cancer patients by microchip technology
- S. Nagrath, L. Sequist, +12 authors M. Toner
- Biology, Medicine
- Nature
- 20 December 2007
Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease.… Expand
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
- M. Yu, A. Bardia, +17 authors S. Maheswaran
- Biology, Medicine
- Science
- 1 February 2013
Cells in Transit(ion) Epithelial-mesenchymal transition (EMT) is a developmental program that converts adherent epithelial cells to a migratory mesenchymal state. This cell-fate change has been… Expand
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
- S. Stott, C. Hsu, +20 authors M. Toner
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 October 2010
Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer provide a potentially accessible source for detection, characterization, and monitoring of nonhematological… Expand
Detection of mutations in EGFR in circulating lung-cancer cells.
- S. Maheswaran, L. Sequist, +15 authors D. Haber
- Medicine
- The New England journal of medicine
- 24 July 2008
BACKGROUND
The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence of… Expand
Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
- E. Ozkumur, A. Shah, +27 authors M. Toner
- Biology, Medicine
- Science Translational Medicine
- 3 April 2013
A multistage microfluidic chip is capable of sorting rare EpCAM+ and EpCAM− CTCs from cancer patients’ whole blood. Positive and Negative Outcomes Usually people want the good news first, to help… Expand
Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility
- Bree B. Aldridge, Marta Fernandez-Suarez, +4 authors S. Fortune
- Biology, Medicine
- Science
- 6 January 2012
Live Fast, Die Faster Treatment of Mycobacterium tuberculosis infections is complicated by the need for a prolonged course of antibiotics to fully eliminate all the bacteria present in an infected… Expand
Circulating tumor cells: approaches to isolation and characterization
- M. Yu, S. Stott, M. Toner, Shyamala Maheswaran, D. Haber
- Biology, Medicine
- The Journal of cell biology
- 7 February 2011
Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with blood components and are thus rare, making their isolation and characterization a major technological… Expand
Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
Staying one step ahead of tumors Cancer treatments require continual adjustment. A drug that works initially will lose its potency as the tumor acquires new mutations that allow it to bypass the… Expand
Long-term storage of tissues by cryopreservation: critical issues.
- J. Karlsson, M. Toner
- Biology, Medicine
- Biomaterials
- 1996
The technique of cryopreservation (maintenance of biological samples in a state of 'suspended animation' at cryogenic temperatures), its potential use in tissue engineering applications and current… Expand