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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammaryExpand
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Isolation of rare circulating tumour cells in cancer patients by microchip technology
Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease.Expand
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Cells in Transit(ion) Epithelial-mesenchymal transition (EMT) is a developmental program that converts adherent epithelial cells to a migratory mesenchymal state. This cell-fate change has beenExpand
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Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
  • S. Stott, C. Hsu, +20 authors M. Toner
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 7 October 2010
Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer provide a potentially accessible source for detection, characterization, and monitoring of nonhematologicalExpand
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Detection of mutations in EGFR in circulating lung-cancer cells.
BACKGROUND The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence ofExpand
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Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
A multistage microfluidic chip is capable of sorting rare EpCAM+ and EpCAM− CTCs from cancer patients’ whole blood. Positive and Negative Outcomes Usually people want the good news first, to helpExpand
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Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility
Live Fast, Die Faster Treatment of Mycobacterium tuberculosis infections is complicated by the need for a prolonged course of antibiotics to fully eliminate all the bacteria present in an infectedExpand
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Circulating tumor cells: approaches to isolation and characterization
Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with blood components and are thus rare, making their isolation and characterization a major technologicalExpand
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Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility
Staying one step ahead of tumors Cancer treatments require continual adjustment. A drug that works initially will lose its potency as the tumor acquires new mutations that allow it to bypass theExpand
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Long-term storage of tissues by cryopreservation: critical issues.
The technique of cryopreservation (maintenance of biological samples in a state of 'suspended animation' at cryogenic temperatures), its potential use in tissue engineering applications and currentExpand
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