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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
View on Elsevier
Isolation of rare circulating tumour cells in cancer patients by microchip technology
TLDR
The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
View on Nature
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
TLDR
A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
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Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
TLDR
A high-throughput microfluidic mixing device, the herringbone-chip, or “HB-Chip,” is described, which provides an enhanced platform for CTC isolation and reveals microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.
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Detection of mutations in EGFR in circulating lung-cancer cells.
TLDR
Molecular analysis of circulating tumor cells from the blood of patients with lung cancer offers the possibility of monitoring changes in epithelial tumor genotypes during the course of treatment, and shows that a reduction in the number of captured cells was associated with a radiographic tumor response; an increase in theNumber of cells wasassociated with tumor progression, with the emergence of additional EGFR mutations in some cases.
View on PubMed
Continuous inertial focusing, ordering, and separation of particles in microchannels
TLDR
The ability to differentially order particles of different sizes, continuously, at high rates, and without external forces in microchannels is expected to have a broad range of applications in continuous bioparticle separation, high-throughput cytometry, and large-scale filtration systems.
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Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
TLDR
A multistage microfluidic device that is capable of sorting rare circulating tumor cells (CTCs) that are either positive or negative for the surface antigen epithelial cell adhesion molecule (EpCAM) and could be a promising addition to current diagnostic tools used in the clinic is developed.
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Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility
TLDR
It is shown that, within a clonal population of mycobacteria, there is deterministic heterogeneity in elongation rate that arises because myCobacteria grow in an unusual, unipolar fashion.
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Circulating tumor cells: approaches to isolation and characterization
TLDR
Improvements in technologies to yield purer CTC populations amenable to better cellular and molecular characterization will enable a broad range of clinical applications, including early detection of disease and the discovery of biomarkers to predict treatment responses and disease progression.
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RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
TLDR
Analysis of circulating tumor cells from prostate cancer patients reveals a mechanism that contributes to treatment failure, and a non-invasive method to spot resistance by sequencing RNA transcripts in single circulating tumor Cells (CTCs) is developed.
View on Science
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