M. Tohkin

Publications27
h-index13
Citations1,026
Highly Influential Citations28
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Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation*
Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further metabolized by soluble… Expand
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Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.
Previously, we have reported a novel proliferative action of pancreatic group I phospholipase A2 (PLA2-I) via a specific binding site in Swiss 3T3 fibroblasts, vascular smooth muscle cells, and… Expand
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Antihepatotoxic principles of Atractylodes rhizomes.
Extracts of various samples of the crude drug prepared from Atractylodes rhizomes exhibited antihepatotoxic activity by in vitro assay methods using carbon tetrachloride- and galactosamine-induced… Expand
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Mechanism of antihepatotoxic activity of glycyrrhizin. I: Effect on free radical generation and lipid peroxidation.
The mechanism of antihepatotoxic action of atractylon, a main sesquiterpenic constituent of ATRACTYLODES rhizomes, was studied. Atractylon inhibited carbon tetrachloride (CCl 4 )-induced cytotoxicity… Expand
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Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.
A 40-kDa protein, in addition to the alpha-subunits of Gs (a GTP-binding protein involved in adenylate cyclase stimulation), was [32P]ADP-ribosylated by cholera toxin (CT) in the membranes of… Expand
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Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes
A wasp venom, mastoparan, rapidly increased the cytosolic free Ca2+ concentration ([Ca2+]i) and activated phosphorylase in rat hepatocytes in a concentration‐dependent manner. Mastoparan could… Expand
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Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes.
Conditions were examined to devise an IN VITRO assay method for antihepatotoxic activity using carbon tetrachloride-induced lesion in primary cultured mouse and rat liver cells. Utilizing 24… Expand
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Assay method for antihepatotoxic activity using galactosamine-induced cytotoxicity in primary-cultured hepatocytes.
Conditions were investigated to devise an in vitro assay method for antihepatotoxic activity using galactosamine-produced injury in primary-cultured mouse and rat liver cells. Employing 1.5-h… Expand
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Antihepatotoxic actions of Allium sativum bulbs.
Garlic constituents, the volatile oil, alliin, S-allylmercaptocysteine (ASSC) and S-methylmercapto-cysteine (MSSC) were subjected to assay for their antihepatotoxic activity using the IN VITRO and IN… Expand
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GTP‐binding proteins in human platelet membranes serving as the specific substrate of islet‐activating protein, pertussis toxin
Two GTP‐binding proteins serving as the specific substrate of islet‐activating protein (IAP), pertussis toxin, were purified from human platelet membranes as heterotrimers with an αβγ‐subunit… Expand
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