Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.
Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms.
Antipsychotic drug effects on brain morphology in first-episode psychosis.
Patients with first-episode psychosis exhibited a significant between-treatment difference in MRI volume changes, and post hoc analyses suggested that treatment effects on brain volume and psychopathology of schizophrenia may be associated.
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
The nearly significant differences suggest that olanzapine might reduce the conversion rate and delay onset of psychosis, and was efficacious for positive prodromal symptoms but induced weight gain.
One hundred years of schizophrenia: A meta-analysis of the outcome literature
Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features.
OBJECTIVE Psychotic affective disorders are the most prevalent idiopathic psychoses, but their outcome from onset has rarely been studied. In this study, the authors determined the rate and latency…
A novel augmentation strategy for treating resistant major depression.
Olanzapine plus fluoxetine demonstrated superior efficacy for treating resistant depression compared to either agent alone.
The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence.
- M. Tohen, C. Zarate, R. Baldessarini
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 December 2003
Within 2-4 years of first lifetime hospitalization for mania, all but 2% of patients experienced syndromal recovery, but 28% remained symptomatic, only 43% achieved functional recovery, and 57% switched or had new illness episodes.
Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: A 47-week study
Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.
Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes.
Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group.
Olanzapine demonstrated greater efficacy than placebo in the treatment of acute bipolar mania and was generally well tolerated.