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Modulation of mammalian life span by the short isoform of p53.
TLDR
Overexpression of the short isoform of p53 (p44) has unexpectedly uncovered a role for p53 in the regulation of size and life span in the mouse, suggesting pathways of gene activity known to regulate longevity in lower organisms are linked in mammals via p53 to mechanisms for controlling cell proliferation. Expand
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
TLDR
Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration. Expand
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
TLDR
Treatment of patients who have acromegaly with pegvisomant with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement. Expand
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
TLDR
A synthetic replicate of this peptide, termed human pancreatic tumour GRF [hpGRF(1–40)]-OH, co-elutes on HPLC with the native peptide and is highly potent in stimulating GH secretion in vitro and in vivo. Expand
Validity of methods of body composition assessment in young and older men and women.
TLDR
The Siri 3-Comp model provides valid and accurate body composition data when compared with a 4-Comp criterion model, however, the individual variability associated with the Siri 2-Comp, DEXA 3-comp, and anthropometric models may limit their use in research settings. Expand
Absence of ghrelin protects against early-onset obesity.
TLDR
It is demonstrated that male Ghrl-/- mice are protected from the rapid weight gain induced by early exposure to a high-fat diet 3 weeks after weaning and showed a paradoxical preservation of the GH/IGF-1 axis, similar to that reported in lean compared with obese humans. Expand
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.
TLDR
Examination of changes in circulating ghrelin and des-acyl gh Relin in response to meals and fasting using newly developed two-site sandwich assays and sample preservation protocols to allow specific detection of full-length forms highlighted the importance of stringent conditions for sample collection and evaluation. Expand
Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations.
TLDR
The results indicate that sex and age have independent and interrelated effects on GH secretion, and an amplifying action of estradiol on the neuroendocrine regulation of pulsatile GH release is suggested. Expand
Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women.
TLDR
Modifications were made to a commercially available human (h) GH chemiluminescence assay (Nichols Luma Tag hGH assay), which improved its sensitivity to 0.002 micrograms/L, which suggested that the lower GH levels in men after glucose treatment are due to lower baseline values and not to a greater suppressive effect of glucose. Expand
Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates.
TLDR
Findings suggest possible mechanisms contributing to the effects of high-protein/low-carbohydrate diets to promote weight loss, and high-fat diets to promotes weight gain. Expand
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