Efficacy of milnacipran in patients with fibromyalgia.
- R. Gendreau, M. Thorn, D. Clauw
- Medicine, PsychologyJournal of Rheumatology
- 1 October 2005
In this Phase II study, milnacipran led to statistically significant improvements in pain and other symptoms of FM, the effect sizes were equal to those previously found with TCA, and the drug was generally well tolerated.
Discontinuing antiepileptic drugs in children with epilepsy. A comparison of a six-week and a nine-month taper period.
- M. Tennison, R. Greenwood, D. Lewis, M. Thorn
- Medicine, PsychologyNew England Journal of Medicine
- 19 May 1994
The risk of seizure recurrence during drug tapering and after the discontinuation of antiepileptic drug therapy in children with epilepsy is not different whether the medications are tapered over a six-week or a nine-month period.
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
- R. A. Torres, M. Barr, J. Thornton
- MedicineAmerican Journal of Medicine
- 1 December 1993
Valproate Metabolites and Hepatotoxicity in an Epileptic Population
- M. Tennison, M. V. Miles, G. Pollack, M. Thorn, R. Dupuis
- Medicine, BiologyEpilepsia
- 1 October 1988
Routine measurement of serum 4‐en‐VPA is unlikely to be a useful predictor of risk for developing fatal hepatotoxicity, as serum levels may not reflect presence or effects in the liver as it may be metabolized to further intermediates or be bound to tissue.
Safety and Efficacy of Epoprostenol in Patients with Severe Congestive Heart Failure
- C. Sueta, M. Gheorghiade, M. Thorn
- Medicine
- 19 January 1995
Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV)
- L. Schwartzberg, S. Barbour, G. Morrow, G. Ballinari, M. Thorn, D. Cox
- MedicineSupportive Care in Cancer
- 19 October 2013
Palonosetron is more effective than older 5HT3 RAs for controlling CINV in the delayed and overall postchemotherapy periods.
Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization
- R. Kleiman, B. Darpo, M. Thorn, T. Stoehr, F. Schippers
- Medicine, BiologyBritish Journal of Clinical Pharmacology
- 6 March 2020
Remimazolam is a new, ultra‐short‐acting benzodiazepine developed for intravenous (IV) use during procedural sedation and in general anaesthesia and its effects on cardiac repolarization are characterized.
Evaluation of the Ames Seralyzer for the Determination of Carbamazepine, Phenobarbital, and Phenytoin Concentrations in Saliva
- M. V. Miles, M. Tennison, A. Ehle
- MedicineTherapeutic Drug Monitoring
- 1 September 1990
The ARIS technique for CBZ, PB, and PHT saliva determination provides acceptable accuracy, precision, and sensitivity for therapeutic monitoring and in practice, the benefits of the ARIS saliva technique, including ease of collection, safety, patient/parent acceptance, and short analysis time, are striking.
Moxifloxacin-induced QTc interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study.
- J. Morganroth, Yaning Wang, R. Shah
- MedicineBritish Journal of Clinical Pharmacology
- 1 September 2015
Moxifloxacin-induced QTc prolongations did not differ significantly between the Japanese and Caucasian subjects, and further studies in other populations and with other QT-prolonging drugs are needed to clarify whether inter-ethnic differences in QT sensitivity exist and whether ethnicity of the study population may affect the outcome of a TQT study.
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