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Efficacy of milnacipran in patients with fibromyalgia.
TLDR
In this Phase II study, milnacipran led to statistically significant improvements in pain and other symptoms of FM, the effect sizes were equal to those previously found with TCA, and the drug was generally well tolerated.
Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
TLDR
Dapsone is as effective as aerosolized pentamidine in preventing PCP and has the advantage of a lower cost, easier administration, and possibly an additional preventive effect against toxoplasmosis, regardless of which prophylactic agent is used.
Safety and Efficacy of Epoprostenol in Patients with Severe Congestive Heart Failure
TLDR
It is suggested that long-term intravenous infusion of epoprostenol is feasible in patients with severe heart failure and hemodynamic and functional results suggest clinical benefit as well.
Discontinuing antiepileptic drugs in children with epilepsy. A comparison of a six-week and a nine-month taper period.
TLDR
The risk of seizure recurrence during drug tapering and after the discontinuation of antiepileptic drug therapy in children with epilepsy is not different whether the medications are tapered over a six-week or a nine-month period.
Valproate Metabolites and Hepatotoxicity in an Epileptic Population
TLDR
Routine measurement of serum 4‐en‐VPA is unlikely to be a useful predictor of risk for developing fatal hepatotoxicity, as serum levels may not reflect presence or effects in the liver as it may be metabolized to further intermediates or be bound to tissue.
Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV)
TLDR
Palonosetron is more effective than older 5HT3 RAs for controlling CINV in the delayed and overall postchemotherapy periods.
Evaluation of the Ames Seralyzer for the Determination of Carbamazepine, Phenobarbital, and Phenytoin Concentrations in Saliva
TLDR
The ARIS technique for CBZ, PB, and PHT saliva determination provides acceptable accuracy, precision, and sensitivity for therapeutic monitoring and in practice, the benefits of the ARIS saliva technique, including ease of collection, safety, patient/parent acceptance, and short analysis time, are striking.
Moxifloxacin-induced QTc interval prolongations in healthy male Japanese and Caucasian volunteers: a direct comparison in a thorough QT study.
TLDR
Moxifloxacin-induced QTc prolongations did not differ significantly between the Japanese and Caucasian subjects, and further studies in other populations and with other QT-prolonging drugs are needed to clarify whether inter-ethnic differences in QT sensitivity exist and whether ethnicity of the study population may affect the outcome of a TQT study.
Vilazodone lacks proarrhythmogenic potential in healthy participants: a thorough ECG study.
TLDR
Vilazodone had no significant effect on cardiac repolarization, heart rate, PR or QRS interval duration, or ECG morphology in healthy adult participants.
Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization
TLDR
Remimazolam is a new, ultra‐short‐acting benzodiazepine developed for intravenous (IV) use during procedural sedation and in general anaesthesia and its effects on cardiac repolarization are characterized.
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