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Functional Recovery and Enhanced Corticofugal Plasticity after Unilateral Pyramidal Tract Lesion and Blockade of Myelin-Associated Neurite Growth Inhibitors in Adult Rats
After a lesion of the mature CNS, structural plasticity and functional recovery are very limited, in contrast to the developing CNS. The postnatal decrease in plasticity is correlated in time withExpand
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Constraint-Induced Movement Therapy in the Adult Rat after Unilateral Corticospinal Tract Injury
Smaller spinal cord injuries often allow some degree of spontaneous behavioral improvements because of structural rearrangements within different descending fiber tracts or intraspinal circuits. InExpand
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Defining the NG2-expressing cell of the adult CNS
The NG2 proteoglycan is believed to be an in vivomarker for oligodendrocyte progenitors found in the developing brain. The prevalence of NG2-expressing cells that remain in the adult CNS followingExpand
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Spatial and temporal gene expression profiling of the contused rat spinal cord
Microarray technology was used to examine gene expression changes following contusive injury of the adult rat spinal cord. To obtain a global understanding of the changes triggered by the injury,Expand
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Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
Anatomical plasticity and functional recovery after lesions of the rodent corticospinal tract (CST) decrease postnatally in parallel with myelin formation. Myelin-associated neurite growth inhibitoryExpand
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Phosphorylated FTY720 promotes astrocyte migration through sphingosine‐1‐phosphate receptors
Sphingosine‐1‐phosphate (S1P) receptors are widely expressed in the central nervous system where they are thought to regulate glia cell function. The phosphorylated version of fingolimod/FTY720Expand
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Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
Nature Neurosci. 1, 124– 131 (1998). We reported in the June 1998 issue of Nature Neuroscience that the monoclonal antibody IN-1 promotes collateral sprouting in the rat spinal cord, red nucleus andExpand
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Nogo-A Regulates Neural Precursor Migration in the Embryonic Mouse Cortex
Although Nogo-A has been intensively studied for its inhibitory effect on axonal regeneration in the adult central nervous system, little is known about its function during brain development. In theExpand
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Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat
Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. WeExpand
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Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis
NG2-expressing cells are the largest proliferating cell population in the adult central nervous system. The function of NG2 proteoglycan or NG2-expressing cells in the adult brain, however, isExpand
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