• Publications
  • Influence
A tutorial on pilot studies: the what, why and how
Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed inExpand
  • 1,593
  • 94
  • PDF
Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis.
BACKGROUND & AIMS Acute gastroenteritis is the strongest risk factor for irritable bowel syndrome (IBS). In May 2000, >2300 residents of Walkerton, Ontario, developed gastroenteritis from microbialExpand
  • 202
  • 13
Systematic review and meta‐analysis: the incidence and prognosis of post‐infectious irritable bowel syndrome
Background  Individual studies suggest that post‐infectious irritable bowel syndrome is common, but symptoms gradually improve.
  • 382
  • 12
Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen.
BACKGROUND & AIMS A large outbreak of acute gastroenteritis at the annual meeting of the Canadian Society of Gastroenterology Nurses and Associates (CSGNA) was attributed to food-borne norovirus. AExpand
  • 194
  • 11
Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery.
BACKGROUND & AIMS Postinfectious irritable bowel syndrome (PI-IBS) is a common clinical phenomenon. To better define its incidence and epidemiology, a large cohort study was initiated after theExpand
  • 353
  • 9
  • PDF
Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
Background : Post‐infectious irritable bowel syndrome is a common clinical phenomenon of uncertain aetiology.
  • 243
  • 8
A tutorial on sensitivity analyses in clinical trials: the what, why, when and how
BackgroundSensitivity analyses play a crucial role in assessing the robustness of the findings or conclusions based on primary analyses of data in clinical trials. They are a critical way to assessExpand
  • 273
  • 7
  • PDF
The Effect of CYP2C19 Polymorphisms on H. pylori Eradication Rate in Dual and Triple First-Line PPI Therapies: A Meta-analysis
PREMISE:It has been suggested that proton pump inhibitor (PPI)-related differences in Helicobacter pylori eradication rates are partly because of CYP2C19 polymorphisms and there have been conflictingExpand
  • 151
  • 5
Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study.
BACKGROUND & AIMS Symptoms of dyspepsia may occur following an episode of acute gastroenteritis, but data are conflicting. We assessed prevalence of uninvestigated dyspepsia in a cohort ofExpand
  • 63
  • 5
Post-infectious irritable bowel syndrome.
Post-infectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS toExpand
  • 111
  • 4