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A tutorial on pilot studies: the what, why and how
Pilot studies for phase III trials - which are comparative randomized trials designed to provide preliminary evidence on the clinical efficacy of a drug or intervention - are routinely performed in… Expand
Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis.
BACKGROUND & AIMS Acute gastroenteritis is the strongest risk factor for irritable bowel syndrome (IBS). In May 2000, >2300 residents of Walkerton, Ontario, developed gastroenteritis from microbial… Expand
Systematic review and meta‐analysis: the incidence and prognosis of post‐infectious irritable bowel syndrome
Background Individual studies suggest that post‐infectious irritable bowel syndrome is common, but symptoms gradually improve.
Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen.
- J. Marshall, M. Thabane, M. Borgaonkar, C. James
- Clinical gastroenterology and hepatology : the…
- 1 April 2007
BACKGROUND & AIMS A large outbreak of acute gastroenteritis at the annual meeting of the Canadian Society of Gastroenterology Nurses and Associates (CSGNA) was attributed to food-borne norovirus. A… Expand
Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery.
- J. Marshall, M. Thabane, A. Garg, W. Clark, M. Salvadori, S. Collins
- 1 August 2006
BACKGROUND & AIMS Postinfectious irritable bowel syndrome (PI-IBS) is a common clinical phenomenon. To better define its incidence and epidemiology, a large cohort study was initiated after the… Expand
Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
- J. Marshall, M. Thabane, A. Garg, W. Clark, J. Meddings, S. Collins
- Alimentary pharmacology & therapeutics
- 1 December 2004
Background : Post‐infectious irritable bowel syndrome is a common clinical phenomenon of uncertain aetiology.
A tutorial on sensitivity analyses in clinical trials: the what, why, when and how
- L. Thabane, L. Mbuagbaw, +14 authors C. Goldsmith
- BMC Medical Research Methodology
- 16 July 2013
BackgroundSensitivity analyses play a crucial role in assessing the robustness of the findings or conclusions based on primary analyses of data in clinical trials. They are a critical way to assess… Expand
The Effect of CYP2C19 Polymorphisms on H. pylori Eradication Rate in Dual and Triple First-Line PPI Therapies: A Meta-analysis
- S. Padol, Y. Yuan, M. Thabane, I. Padol, R. Hunt
- The American Journal of Gastroenterology
- 1 July 2006
PREMISE:It has been suggested that proton pump inhibitor (PPI)-related differences in Helicobacter pylori eradication rates are partly because of CYP2C19 polymorphisms and there have been conflicting… Expand
Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study.
BACKGROUND & AIMS Symptoms of dyspepsia may occur following an episode of acute gastroenteritis, but data are conflicting. We assessed prevalence of uninvestigated dyspepsia in a cohort of… Expand
Post-infectious irritable bowel syndrome.
Post-infectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS to… Expand