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Facile enzymatic preparation of monoacylated sugars in pyridine
Regioselective acylation of secondary hydroxyl groups in sugars catalyzed by lipases in organic solvents
New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases.
- M. Fonvielle, P. Weber, K. Dabkowska, M. Thérisod
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 7 June 2004
Phosphoglycolo amidoxime and phosphoglycolo hydrazide, two new derivatives of phosphoglycolic acid, were synthesised and successfully tested as selective competitive inhibitors of class II… Expand
Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli*
- Maria de la Paz Santangelo, Petra M Gest, +13 authors M. Jackson
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 September 2011
Background: New drugs active against persistent Mycobacterium tuberculosis are needed. Results: The fructose-1,6-bisphosphate aldolase (FBA-tb) is essential for growth of M. tuberculosis, is… Expand
The biosynthesis of thiamine. Syntheses of [1,1,1,5-2H4]-1-deoxy-D-threo-2-pentulose and incorporation of this sugar in biosynthesis of thiazole by Escherichia coli cells
Non-growing, washed cells of Escherichia coli, depressed for the synthesis of thiamine, were incubated in the presence of [1,1,1,5-2H4]-1-deoxy-D-threo-2-pentulose (9) in a medium containing the… Expand
Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.
- R. Daher, M. Coinçon, +5 authors M. Thérisod
- Chemistry, Medicine
- Journal of medicinal chemistry
- 7 October 2010
We report the synthesis and biochemical evaluation of several selective inhibitors of class II (zinc dependent) fructose bis-phosphate aldolases (Fba). The products were designed as transition-state… Expand
Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics.
We report the synthesis and biochemical evaluation of selective inhibitors of class II (zinc-dependent) fructose bisphosphate aldolases. The most active compound is a simplified analogue of fructose… Expand
Enzymatic synthesis of aldonic acids.
Several aldonic acids (D-mannonic, D-galactonic, D-xylonic, 2-deoxy-D-arabinohexonic (2-deoxy-D-gluconic)) were prepared on a scale of several grams by a simple oxidation catalyzed by glucose oxidase… Expand
1-Deoxy-D-threo-2-pentulose: the precursor of the five-carbon chain of the thiazole of thiamine