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Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular function.
The mechanisms by which activated RTKs and the downstream targets eNOS and VE-cadherin may be internalized and transported to various intracellular compartments are discussed.
EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells.
It is shown that a 4-week exposure of immortalized human bronchial epithelial cells (HBEC) to tobacco carcinogens can induce a persistent, irreversible, and multifaceted dedifferentiation program marked by EMT and the emergence of stem cell-like properties.
Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis
- M. Tessema, D. Klinge, C. M. Yingling, K. Do, L. van Neste, S. Belinsky
- Biology, MedicineOncogene
- 2 June 2010
CXCL14 methylation in sputum from asymptomatic early-stage lung cancer cases was associated with a 2.9-fold elevated risk for this disease compared with controls, substantiating its potential as a biomarker for early detection of lung cancer.
Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25.
The results indicate that frequent inactivation of multiple candidate tumor suppressor genes within chromosome 6q likely contributes to development of sporadic lung cancer.
SULF2 Methylation is Prognostic for Lung Cancer Survival and Increases Sensitivity to Topoisomerase-I inhibitors via Induction of ISG15
High ISG15 expression that is comparable to the topotecan (TPT)-sensitive NSCLC cell lines was found in tumors from 25% ofNSCLC patients compared with normal lung, indicating a potential to identify and target the most sensitive NS CLC subpopulation for personalized TPT therapy.
Cell cycle and no end
Properties of the molecular circuits regulating the duplication of the genetic material and the subsequent division of a cell into two daughter cells, and the molecular mechanisms of actual cell division, are described in detail.
Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7.
Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.
The data suggest a disturbed regulation of the IGF-2/H19 locus in myeloid leukemias which is not caused by loss of imprinting.
Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers
A novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter and the impact on tissue remodeling, inflammatory response, and cell differentiation pathways suggest a potential role for ToX2 in modulating tumor microenvironment.
Functional Identification of Cancer-Specific Methylation of CDO1, HOXA9, and TAC1 for the Diagnosis of Lung Cancer
A three-gene panel, CDO1, HOXA9, and TAC1, which is 100% specific, showing no methylation in 75 TCGA normal and seven primary normal samples and is 83% to 99% sensitive for NSCLC depending on the cohort, may be of high value to diagnose the earliest stages ofNSCLC.