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Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.
TLDR
Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year and Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect. Expand
Clinical characteristics of patients in a case control study of sarcoidosis.
TLDR
It is concluded that the initial presentation of sarcoidosis is related to sex, race, and age. Expand
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.
TLDR
Adult patients taking hydroxyurea for frequent painful sickle cell episodes appear to have reduced mortality after 9 of years follow-up, and indications for hydroxyUREa treatment should be expanded. Expand
Liberal or restrictive transfusion in high-risk patients after hip surgery.
TLDR
A liberal transfusion strategy, as compared with a restrictive strategy, did not reduce rates of death or inability to walk independently on 60-day follow-up or reduce in-hospital morbidity in elderly patients at high cardiovascular risk. Expand
Cluster-Randomized Trial of a Mobile Phone Personalized Behavioral Intervention for Blood Glucose Control
TLDR
The combination of behavioral mobile coaching with blood glucose data, lifestyle behaviors, and patient self-management data individually analyzed and presented with evidence-based guidelines to providers substantially reduced glycated hemoglobin levels over 1 year. Expand
Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease.
TLDR
Clinical evaluation, though nonspecific, is of considerable value in the selection of patients in whom there is a need for further diagnostic studies. Expand
A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission.
TLDR
This study demonstrates that a six-month, multidisciplinary approach to CHF management can improve important clinical outcomes at a similar cost in recently hospitalized high-risk patients with CHF. Expand
Two year prognosis of sarcoidosis: the ACCESS experience.
TLDR
It is indicated that sarcoidosis tends to improve or remain stable over two years in the majority of patients, and changes in FVC alone were inadequate to describe the change in pulmonary status of the patients, as changes in chest radiographic findings or the level of dyspnea did often but not always move in the same direction as FVC. Expand
Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction
TLDR
Increased morbidity due to hemorrhagic complications is associated with an invasive management strategy in patients with acute myocardial infarction and the complex interaction of several factors in the occurrence of hemorrhagic events during thrombolytic therapy is shown. Expand
Hydroxyurea and Sickle Cell Anemia Clinical Utility of a Myelosuppressive “Switching” Agent
TLDR
The trial was closed earlier than expected, after demonstration that median crisis rate was reduced by almost 50% (2.5 versus 4.5 crises per year) in patients assigned to HU therapy and there was strong evidence of independent association of lower neutrophil counts with lower crisis rates. Expand
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