M. Telford

Publications134
h-index42
Citations7,671
Highly Influential Citations519
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TranslatorX: multiple alignment of nucleotide sequences guided by amino acid translations
TLDR
TranslatorX is presented, a web server designed to align protein-coding nucleotide sequences based on their corresponding amino acid translations, with a rich output, including Jalview-powered graphical visualization of the alignments, codon-based alignments coloured according to the corresponding amino acids, measures of compositional bias and first, second and third codon position specific alignments. Expand
Acoelomorph flatworms are deuterostomes related to Xenoturbella
TLDR
This phylogeny makes sense of the shared characteristics of Xenoturbellida and Acoelomorpha, and implies the loss of various deuterostome characters in the Xenobiology including coelomic cavities, through gut and gill slits. Expand
Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida
TLDR
To study the relationships among all deuterostome groups, an alignment of more than 35,000 homologous amino acids is assembled, including new data from a hemichordate, starfish and Xenoturbella and it is concluded that chordates are monophyletic. Expand
MicroRNAs and phylogenomics resolve the relationships of Tardigrada and suggest that velvet worms are the sister group of Arthropoda
TLDR
The study confirms the monophyly of the legged ecdysozoans, shows that past support for a Tardigrada + Nematoda group was due to long-branch attraction, and suggests that the velvet worms are the sister group to the arthropods. Expand
Consideration of RNA secondary structure significantly improves likelihood-based estimates of phylogeny: examples from the bilateria.
TLDR
A novel permutation approach is used to demonstrate the significant superiority of models of sequence evolution that allow stem and loop regions to evolve according to separate models and it is shown that 16-state models that take base pairing of stems into account are significantly better than simpler, 4-state, single-nucleotide models. Expand
Hox genes and the phylogeny of the arthropods
TLDR
The data support the hypothesis that insects and crustaceans form a single clade within the arthropods to the exclusion of myriapods and suggest that myriAPods are more closely allied to the chelicerates than to this insect/crustacean clade. Expand
Xenoturbella is a deuterostome that eats molluscs
TLDR
It is shown that the samples in these studies were contaminated by bivalve embryos eaten by Xenoturbella and that XenOTurbella is in fact a deuterostome related to hemichordates and echinoderms. Expand
Phylogenomics
don’t need to be told a reason for conserving species, but for many people (including those with the most money), the case does need to be made. Discovering and illustrating the remarkable cognitive… Expand
A congruent solution to arthropod phylogeny: phylogenomics, microRNAs and morphology support monophyletic Mandibulata
TLDR
The phylogenomic analyses strongly support Mandibulata, and show that Myriochelata is a tree-reconstruction artefact caused by saturation and long-branch attraction, and provide strong support for the inclusion of pycnogonids in a monophyletic Chelicerata, a paraphyletic Cycloneuralia, and a common origin of Arthropoda. Expand
Expression of homeobox genes shows chelicerate arthropods retain their deutocerebral segment.
TLDR
Embrailed expression, which has been used to demonstrate the presence of segments in insects, fails to demonstrate a reduced deutocerebral segment and further inferences are made concerning the evolution of heads and Hox genes in arthropods. Expand
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