• Publications
  • Influence
Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis.
PTH-related protein (PTHrP) is homologous with PTH. PTH, an effective anabolic agent for treating osteoporosis, has been shown to stimulate both bone resorption by osteoclasts and bone formation byExpand
  • 172
  • 13
Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25-dihydroxyvitamin D concentrations, and
PTH and PTH-related protein (PTHrP) cause primary hyperparathyroidism and humoral hypercalcemia of malignancy (HHM), respectively. These syndromes are similar in several important ways, but differ inExpand
  • 100
  • 7
Lactation and bone turnover: a conundrum of marked bone loss in the setting of coupled bone turnover.
CONTEXT Mothers who exclusively breastfeed lose up to 10% of their bone mass. This is primarily mediated by PTHrP, in combination with low estrogen levels. The mechanisms underlying this marked boneExpand
  • 40
  • 3
A 7‐day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover
Human in vivo models of primary hyperparathyroidism (HPT), humoral hypercalcemia of malignancy (HHM), or lactational bone mobilization for more than 48 hours have not been described previously. WeExpand
  • 34
  • 3
Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D
Osteoblast activity and plasma 1,25(OH)2vitamin D are increased in HPT but suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous infusions of PTH versus PTHrP in humans.Expand
  • 98
  • 1
Parathyroid hormone-related protein-(1--36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy.
All would agree that hypercalcemia occurs among patients with humoral hypercalcemia of malignancy (HHM) as a result of osteoclastic bone resorption. Some studies suggest that enhanced renal calciumExpand
  • 51
  • 1
Evaluation of markers of bone turnover during lactation in African-Americans: a comparison with Caucasian lactation.
CONTEXT The African-American skeleton is resistant to PTH; whether it is also resistant to PTHrP and the hormonal milieu of lactation is unknown. OBJECTIVES The objective of the study was to assessExpand
  • 7
  • 1
Glimepiride improves both first and second phases of insulin secretion in type 2 diabetes.
OBJECTIVE The purpose of this study was to assess the effect of glimepiride on insulin sensitivity and secretion in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS After a 2-week washoutExpand
  • 59
  • PDF
MENSTRUAL AND REPRODUCTIVE FUNCTION IN WOMEN WITH TYPE 1 DIABETES.
OBJECTIVE Menstrual irregularities, reproductive abnormalities, and androgen excess are reported to be more prevalent in women with type 1 diabetes (T1D). The objective of this study was toExpand
  • 5
Glucodynamics and pharmacokinetics of 70/30 vs. 50/50 NPH/regular insulin mixtures after subcutaneous injection.
Optimal insulin therapy for many patients with type 1 and type 2 diabetes requires the use of combinations of short- and intermediate-acting insulin preparations. A significant number of patientsExpand
  • 1