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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit theExpand
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An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.
Although human cancers have complex genotypes and are genomically unstable, they often remain dependent on the continued presence of single-driver mutations-a phenomenon dubbed "oncogene addiction."Expand
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Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Short hairpin RNAs (shRNAs) are versatile tools for analyzing loss-of-function phenotypes in vitro and in vivo. However, their use for studying genes involved in proliferation and survival, which areExpand
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Simple Application Messaging Protocol Version 1.3
TLDR
SAMP is a messaging protocol that enables astronomy software tools to interoperate and communicate. Expand
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A Comparison of learning gains when using a 2D simulation tool versus a 3D virtual world: An experiment to find the right representation involving the Marginal Value Theorem
TLDR
The use of three-dimensional Virtual Worlds in the classroom offers the promise of engaging and authentic learning experiences. Expand
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Designing in virtual reality (DesIRe): a gesture-based interface
TLDR
In this paper, we focus on detection of dynamic gestures and find the thresholds to detect gestures for a gesture-based system, DesIRe (DESigning In virtual REality). Expand
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Student Response Systems and Learning: Perceptions of the Student
ABSTRACT To assess student perception of learning and use of a student response system (SRS) as a teaching/learning strategy. Survey methods were used to explore student perceptions of learning andExpand
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Expertise Recommendation: A Two-Way Knowledge Communication Channel
TLDR
In our service-based society, expertise is becoming increasingly recognized as a valuable and scarce resource. Expand
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Finding and validating expertise
TLDR
We designed a triangulated approach which combines automated expert profile creation and maintenance, validation by the expert, and feedback on the expert and the system by the searching party. Expand
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Assessment and Continuous Planning: The Key to Transformation at the University of Texas Libraries
TLDR
This paper presents a case study of the continuous planning process that the University of Texas at Austin Libraries (“UT Libraries”) has been implementing since September 2010. Expand
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